In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood

The modern view on the role of glyprolines by metabolic syndrome

“…63 In addition, the effects may be related to the property of glyproline peptides like heparin to reduce the atherogenic properties of blood through activation of blood lipoprotein lipase. 64 The results obtained indicate the potential of the studied compounds to influence homeostatic processes, change the metabolism and functions of cells, participate in the regulation of metabolism, and maintain metabolic balance. These results provide new factual material that characterizes the features of structural and functional interaction that underlie the ability of the studied regulatory peptides to influence the body's homeostasis.…”

“…The studied glyprolines affected lipid and carbohydrate metabolism, reducing LDL‐C and triglycerides in the blood, as well as the level of blood glucose, which is due to their structural features and due to the additional action of individual amino acids included in their composition 63 . In addition, the effects may be related to the property of glyproline peptides like heparin to reduce the atherogenic properties of blood through activation of blood lipoprotein lipase 64 . The results obtained indicate the potential of the studied compounds to influence homeostatic processes, change the metabolism and functions of cells, participate in the regulation of metabolism, and maintain metabolic balance.…”