2021
DOI: 10.3390/molecules27010155
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Diabetes mellitus (DM) is a chronic metabolic condition that can lead to significant complications and a high fatality rate worldwide. Efforts are ramping up to find and develop novel α-glucosidase and α-amylase inhibitors that are both effective and potentially safe. Traditional methodologies are being replaced with new techniques that are less complicated and less time demanding; yet, both the experimental and computational strategies are viable and complementary in drug discovery and development. As a resul… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 19 publications
(8 citation statements)
references
References 64 publications
0
8
0
Order By: Relevance
“…Essentially, the regulation of α-amylase and α-glucosidase biological functions (inhibition) is critical to the treatment regimen. This implies that new drug candidates with a potent inhibition of the α-glucosidase and α-amylase would be valuable to drug discovery and development for diabetes mellitus [ 30 ].…”
Section: Resultsmentioning
confidence: 99%
“…Essentially, the regulation of α-amylase and α-glucosidase biological functions (inhibition) is critical to the treatment regimen. This implies that new drug candidates with a potent inhibition of the α-glucosidase and α-amylase would be valuable to drug discovery and development for diabetes mellitus [ 30 ].…”
Section: Resultsmentioning
confidence: 99%
“…In the same study, it was also indicated that the extracts inhibited alpha-amylase and alpha-glucosidase activities in a dose-dependent manner as compared to the respective positive controls. In another study [ 86 ], the aqueous acetone extract of H. petiolare was shown to display an increased glucose uptake in HepG2 cells in a concentration-dependent manner and had moderate inhibitory effects against alpha-amylase and alpha-glucosidase activity compared to the acarbose, the positive control used in the study.…”
Section: Resultsmentioning
confidence: 99%
“…17 Natural products are known to be more complex compared to synthetic compounds and exhibit chemical diversity, thus occupying larger chemical space regions than synthetic origin drugs. 18 In our study, the phytoconstituents have been analyzed that may be responsible for the nephroprotective potential of the ZME. The HPTLC fingerprint showed the presence of naringenin in the ZME.…”
Section: Discussionmentioning
confidence: 99%