In Vitro Evaluation of the Photoprotective Potential of Quinolinic Alkaloids Isolated from the Antarctic Marine Fungus Penicillium echinulatum for Topical Use

Teixeira, Thaiz Rodrigues; Rangel, Karen Cristina; Tavares, Renata Spagolla Napoleão; Kawakami, Camila Martins; Santos, Gustavo Souza; Maria-Engler, Silvya Stuchi; Colepicolo, Pio; Gaspar, Lorena Rigo; Debonsi, Hosana Maria

doi:10.1007/s10126-021-10030-x

Cited by 14 publications

(16 citation statements)

References 73 publications

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“…On the one hand, under oxidative stress, excess ROS could overwhelm endogenous antioxidants (T-SOD, CAT, GPX1, etc. ), leading to irreversible accumulation in cells [24,25], thus…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, under oxidative stress, excess ROS could overwhelm endogenous antioxidants (T-SOD, CAT, GPX1, etc. ), leading to irreversible accumulation in cells [24,25], thus damaging the mitochondrial structure, collapsing the mitochondrial membrane potential, and initiating key apoptotic events. In this research, the generation of ROS was enhanced by UVB stimulation.…”

Section: Discussionmentioning

confidence: 99%

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Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Zheng

Xiao

et al. 2021

Marine Drugs

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Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from Isochrysis zhanjiangensis which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from I. zhanjiangensis, exhibits protective effects against UVB-induced damage.

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“…On the one hand, under oxidative stress, excess ROS could overwhelm endogenous antioxidants (T-SOD, CAT, GPX1, etc. ), leading to irreversible accumulation in cells [24,25], thus…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Zheng

Xiao

et al. 2021

Marine Drugs

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“…Marine fungi Penicillium echinulatum was reported for producing photoprotective alkaloids (46–49), all the four metabolites being mainly absorbers of UVB and UVA radiation. Metabolites 48 and 49 were identified in major quantity in the collected extract, with critical wavelength (λ c ) of 335 nm and 334 nm, respectively [ 123 ]. Among all the compounds, 49 was the most successful in inhibiting the generation of ROS through UVA-photoinduced damage in irradiated HaCaT keratinocyte cells, demonstrating its high potential as a future photoprotective compound.…”

Section: Prospectsmentioning

confidence: 99%

“…Five metabolites (50–54) produced by red algae Bostrychia radicans -associated fungus Annulohypoxylon stygium presented high photostability when irradiated, showing loss of absorbance (LoA) not higher than 5% [ 124 ]. However, when compared with compounds 46–49 [ 123 ], they possess phototoxicity, with photoirritation factor (PIF) values up to 5, with the exception of metabolites 50 and 51 [ 124 ].…”

Section: Prospectsmentioning

confidence: 99%

UV Filters: Challenges and Prospects

et al. 2022

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The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Particularly, the negative impact in marine organisms has recently raised concern on the scientific community. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives, such as benzimidazoles, benzotriazoles, hydroxycinnamic acids, xanthones, triazines, among others, have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. Herein, we provide the reader with an overview about UV filters’ challenges and prospects, offering a forward-looking to the next-generation of UV filters.

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“…O Helioguard 365 da empresa Mibelle Biochemistry (MIBELLE GROUP, Suíça), por exemplo, é uma matéria prima utilizada em fotoprotetores, extraído de algas vermelhas Porphyra umbilicalis. Além dos compostos produzidos por algas, também é descrito na literatura que algumas espécies de fungos também produzem substâncias que absorvem radiação na região do UV (TORRES et al, 2004;PALLELA et al, 2010;RANGEL et al, 2020;TEIXEIRA et al, 2021).…”

Section: Introductionunclassified

Avaliação do potencial fotoprotetor de fungos marinhos isolados do continente Antártico

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In Vitro Evaluation of the Photoprotective Potential of Quinolinic Alkaloids Isolated from the Antarctic Marine Fungus Penicillium echinulatum for Topical Use

Cited by 14 publications

References 73 publications

Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

UV Filters: Challenges and Prospects

Avaliação do potencial fotoprotetor de fungos marinhos isolados do continente Antártico

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