RETRACTED ARTICLE: In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line

Abstract

MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique. Toxicity-dependent parameters were assessed in a HeLa cell model after annealing the grown samples at 350 °C, 450 °C, and 550 °C. After the overall characterization, an analysis of toxicity caused by changes in the MgO nanostructure morphology was tested in a HeLa cell model using a neutral red assay and microscopy. The feasibility of using MgO for PDT was assessed. Empirical modelling was applied to corroborate the experimental results obtained from assessing cell viability losses and reactive oxygen species. The results indicate that MgO is an excellent candidate material for medical applications and could be utilized for its potential ability to upgrade conventionally used techniques.

Novel 3‐aryl‐5‐substituted‐coumarin analogues: Synthesis and bioactivity profile

“…SK‐N‐SH human neuroblastoma cell line was selected to allow comparisons on the cytotoxic activity evaluation of hydroxy and oxyprenylated coumarin derivatives studied previously by our group (Kavetsou et al, ). Both SK‐N‐SH and HeLa cells have been widely used to examine the anticancer effect of bioactive agents (Akram et al, ; Dickens et al, ; Goswami et al, ; Park et al, ; Qi et al, ; Swift, Zhang, Trippett, & Narendran, ; Yen et al, ).…”

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

“…To characterize and determine functional groups and modifications, FTIR 139 spectroscopy was performed on pure MgO-NPs, PEG and 2ME as well as in MgO-PEG, 140 MgO-PEG-2ME NPs and PEG-2ME. Fig 3A shows vibration [19,20] and at 846 cm −1 which has been attributed to the formation of cubic 144 phase of MgO [19]. The FTIR PEG shows the characteristic bands at 2929 cm −1 , 2888 145 cm −1 , 1342 cm −1 , 1242 cm −1 and 1100 cm −1 that have been described by [21,22].…”

“…When PEG is added to NPs we can observe that the bands are modified, with respect to 147 pure MgO-NPs mainly at 1098 cm −1 (C-O streching vibration) [19], this band is shifted 148 at 1081 cm −1 from their original position in pure PEG, exhibiting hydrogen-bonding 149 nature and suggests that PEG interaction with the surface of MgO-NPs [19]. The FTIR 150 spectrum of pure 2ME exhibit characteristic bands occurring at 3417 cm −1 , 3182 cm −1 , 151 3000 cm −1 , 2963 cm −1 , 2907 cm −1 , 2809 cm −1 , and 1600 cm −1 , and also in the ranges 152 between 1500-1400 cm −1 and 1300-1000 cm −1 , the last bands are the fingerprint of 153 2ME, that have been described previously by our research group [9].…”

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

“…has been opening a new horizon in the area of biomedical sciences. For the confirmation of the hybrid form and relevant investigation, many successful experiments were conducted in this context by applying assessment analysis of zeta potential, cell viability, cellular internalization, and lipid oxidation test for an NIH 3T3 cell model [25]. Lipid assembled for combined chemotherapy is very convincing and up to the marking technique, but PDT/PTT is more favorable due to less invasiveness.…”