In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds

Myakinin, Alexandr; Turlybekuly, Amanzhol; Pogrebnjak, A.D.; Mirek, A.; Bechelany, Mikhael; Liubchak, Iryna; Oleshko, Oleksandr; Husak, Yevheniia; Korniienko, Viktoriia; Leśniak-Ziółkowska, Katarzyna; Dogadkin, Dmitry; Banasiuk, Rafał; Moskalenko, Roman; Pogorielov, Мaksym; Simka, Wojciech

doi:10.1016/j.msec.2021.111870

Cited by 39 publications

(24 citation statements)

References 76 publications

(106 reference statements)

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“…Therefore, it has become important to increase the biological activity of titanium alloy implants, which is the focus of several ongoing research studies. Changing the surface morphology of implants (such as the surface of micro-nano structures produced by MAO) or preparing implant coatings (such as HA coatings) are two effective methods to solve this problem ( Su et al, 2020 ; Myakinin et al, 2021 ). In the process of implant surface modification, these methods enhance the biological activity of the implant and promote osseointegration.…”

Section: Functionalization Of the Implant Surfacementioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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Section: Functionalization Of the Implant Surfacementioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Implants were immersed in DMEM overnight to equalize pH. cells were seeded on each sample and in the wells without samples (as positive control) at a cell density of 10 4 cells per well as described in [45]. Alamar blue colorimetric assay used to measure cell viability in 1, 3 and 5 days after cell seeding.…”

Section: Cell Culturementioning

confidence: 99%

Bioactivity Performance of Pure Mg after Plasma Electrolytic Oxidation in Silicate-Based Solutions

et al. 2021

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The biodegradable metals, including magnesium (Mg), are a convenient alternative to permanent metals but fast uncontrolled corrosion limited wide clinical application. Formation of a barrier coating on Mg alloys could be a successful strategy for the production of a stable external layer that prevents fast corrosion. Our research was aimed to develop an Mg stable oxide coating using plasma electrolytic oxidation (PEO) in silicate-based solutions. 99.9% pure Mg alloy was anodized in electrolytes contained mixtures of sodium silicate and sodium fluoride, calcium hydroxide and sodium hydroxide. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), contact angle (CA), Photoluminescence analysis and immersion tests were performed to assess structural and long-term corrosion properties of the new coating. Biocompatibility and antibacterial potential of the new coating were evaluated using U2OS cell culture and the gram-positive Staphylococcus aureus (S. aureus, strain B 918). PEO provided the formation of a porous oxide layer with relatively high roughness. It was shown that Ca(OH)2 was a crucial compound for oxidation and surface modification of Mg implants, treated with the PEO method. The addition of Ca2+ ions resulted in more intense oxidation of the Mg surface and growth of the oxide layer with a higher active surface area. Cell culture experiments demonstrated appropriate cell adhesion to all investigated coatings with a significantly better proliferation rate for the samples treated in Ca(OH)2-containing electrolyte. In contrast, NaOH-based electrolyte provided more relevant antibacterial effects but did not support cell proliferation. In conclusion, it should be noted that PEO of Mg alloy in silicate baths containing Ca(OH)2 provided the formation of stable biocompatible oxide coatings that could be used in the development of commercial degradable implants.

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“…The control of the scaffold’s architecture represents an effective approach to tailor its properties. A representative example is given by scaffolds with triply periodic minimal surface architecture, whose mechanical properties can be optimized in a very precise way by varying their porosity, wall thickness, and cell size [ 21 ]. Different AM techniques have been investigated to fabricate PHA scaffolds for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Poly(D,L-lactide-co-glycolide) Biphasic Scaffolds for Bone Tissue Regeneration

Pecorini

Braccini

Parrini

et al. 2022

IJMS

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Polyhydroxyalkanoates are biopolyesters whose biocompatibility, biodegradability, environmental sustainability, processing versatility, and mechanical properties make them unique scaffolding polymer candidates for tissue engineering. The development of innovative biomaterials suitable for advanced Additive Manufacturing (AM) offers new opportunities for the fabrication of customizable tissue engineering scaffolds. In particular, the blending of polymers represents a useful strategy to develop AM scaffolding materials tailored to bone tissue engineering. In this study, scaffolds from polymeric blends consisting of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(D,L-lactide-co-glycolide) (PLGA) were fabricated employing a solution-extrusion AM technique, referred to as Computer-Aided Wet-Spinning (CAWS). The scaffold fibers were constituted by a biphasic system composed of a continuous PHBV matrix and a dispersed PLGA phase which established a microfibrillar morphology. The influence of the blend composition on the scaffold morphological, physicochemical, and biological properties was demonstrated by means of different characterization techniques. In particular, increasing the content of PLGA in the starting solution resulted in an increase in the pore size, the wettability, and the thermal stability of the scaffolds. Overall, in vitro biological experiments indicated the suitability of the scaffolds to support murine preosteoblast cell colonization and differentiation towards an osteoblastic phenotype, highlighting higher proliferation for scaffolds richer in PLGA.

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In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds

Cited by 39 publications

References 76 publications

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Bioactivity Performance of Pure Mg after Plasma Electrolytic Oxidation in Silicate-Based Solutions

Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Poly(D,L-lactide-co-glycolide) Biphasic Scaffolds for Bone Tissue Regeneration

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