In vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on ovarian, pituitary, and pineal function in pigs

Jabłońska, Olga; Piasecka, Joanna; Petroff, Brian K.; Nynca, Anna; Siawrys, Gabriela; Wąsowska, Barbara; Zmijewska, Agata; Lewczuk, Bogdan; Ciereszko, Renata E.

doi:10.1016/j.theriogenology.2011.04.023

Cited by 20 publications

(13 citation statements)

References 36 publications

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“…In rats, exposure to TCDD (0.3 – 60 μg/kg/day) reduced preovulatory peak concentrations of FSH and LH, however, the mechanism is not clear (as reviewed in Petroff et al 2001). In pig pituitary cell cultures, exposure to TCDD (100 nmol/L) altered the secretion of prolactin during both the follicular and luteal phases and induced LH secretion during the follicular phase (Jablonska et al 2011). …”

Section: Tcddmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

258

150

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Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

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Section: Tcddmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

258

150

View full text Add to dashboard Cite

show abstract

“…TCDD is an endocrine disruptor and its effects on AhR signaling are well known and have been demonstrated in vitro and in vivo (Jablonska et al, 2011;Hrabia et al, 2013). AhR is a ligand-activated transcription factor.…”

Section: Discussionmentioning

confidence: 99%

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Chu¹,

Cruz²,

Hwang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…) and theca interna (Jablonska et al. ) cells were isolated from medium (3–6 mm) and pre‐ovulatory (≥8 mm) porcine follicles. Only well vascularized follicles that contained clear follicular fluid were selected for the study.…”

Section: Methodsmentioning

confidence: 99%

The Expression of Aryl Hydrocarbon Receptor in Porcine Ovarian Cells

Jabłońska

Ciereszko

2013

Reprod Domestic Animals

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The aryl hydrocarbon receptor (AHR) is an intracellular transcription factor best known for mediating the toxicity of dioxins. The AHR is phylogenetically highly conserved among invertebrates and vertebrates and may play a significant role in the regulation of physiological processes including female reproduction. This study was performed to determine the partial nucleotide sequence of porcine AHR and to evaluate the AHR mRNA (real-time PCR) and AHR protein (Western blot) expression in granulosa and theca interna cells harvested from medium (3-6 mm) and pre-ovulatory (≥8 mm) follicles as well as in luteal cells obtained from corpora lutea collected during the mid-luteal phase (days: 8-10) of the porcine oestrous cycle. In the study, the partial nucleotide sequence of porcine AHR containing 1021 bp (GenBank accession no: HM488957.1) was determined. The AHR transcript and protein were found in all ovarian cells obtained during both phases of the porcine oestrous cycle. The highest AHR transcript level was detected in theca interna cells isolated from pre-ovulatory follicles as well as in luteal cells. Higher AHR protein expression was found in granulosa cells isolated from pre-ovulatory follicles in comparison with all remaining cell types. The presence of AHR in the examined ovarian cells may account for their sensitivity to some environmental pollutants. Moreover, the differences found in AHR mRNA expression between granulosa and theca cells as well as between cells originating from follicles of different size suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.

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In vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on ovarian, pituitary, and pineal function in pigs

Cited by 20 publications

References 36 publications

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

The Expression of Aryl Hydrocarbon Receptor in Porcine Ovarian Cells

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