In vitro effect of heather (Ericaceae) extracts on different development stages of Teladorsagia circumcincta and Haemonchus contortus

Moreno-Gonzalo, Javier; Manolaraki, Foteini; Frutos, Pilar; Hervás, Gonzalo; Celaya, R.; Osoro, K.; Ortega‐Mora, Luis Miguel; Hoste, Hervé; Ferre, Ignacio

doi:10.1016/j.vetpar.2013.05.010

Cited by 19 publications

(17 citation statements)

References 43 publications

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“…This is a first example for which a whole series of consistent results were obtained that covered in vitro assays (e.g. Moreno-Gonzalo et al, 2013), controlled in vivo studies with experimental infections in confined conditions (Frutos et al, 2008;Moreno-Gonzalo et al, 2014) and systemic studies with natural infections (Osoro et al, 2009).…”

Section: Exploring Plant Resources As Nutraceuticals: Example Of Othementioning

confidence: 69%

Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock

Hoste¹,

Torres-Acosta²,

Sandoval-Castro³

et al. 2015

Veterinary Parasitology

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Parasitic infections with gastrointestinal nematodes (GINs) still represent a worldwide major pathological threat associated with the outdoor production of various livestock species. Because of the widespread resistance to synthetic chemical anthelmintics, there is a strong impetus to explore novel approaches for a more integrated management of these infections. The use of nutraceuticals in the control of GINs is one of the alternatives which has been widely studied for 20 years. The objectives of this review are: (i) to define and illustrate the concept of 'nutraceutical' in the context of veterinary parasitology based on data obtained on the most studied models to control GINs in small ruminants, the tannin-containing legumes (Fabaceae); (ii) to illustrate how the 'nutraceutical concept' could be expanded to other plants, other livestock production systems and other GI parasitic diseases, and (iii) to explain how this concept is opening up new research fields for better understanding the interactions between the host, the digestive parasites and the environment.

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Section: Exploring Plant Resources As Nutraceuticals: Example Of Othementioning

confidence: 69%

Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock

Hoste¹,

Torres-Acosta²,

Sandoval-Castro³

et al. 2015

Veterinary Parasitology

Self Cite

210

179

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show abstract

“…In this review, antiparasitic effects of plants vary depending on the plant species, stage, the nematode species and the parasitic stage. Erica cinera was more active against eggs and L 3 of T. columbriformis than to inhibit the egg hatching and larvae exsheathment of abomasal parasites ( H. contortus and T. circumcinta ) (Moreno-Gonzalo et al ., 2013 a , 2013 b ). The Agave sisalana and Moringa oleifera has greater ovicidal effect while Acacia nilotica and A. raddiana are more active against L 3 of GIN (Botura et al ., 2013; Zabré et al ., 2017; De Medeiros et al ., 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have showed the anthelmintic potential of the plants rich in condensed tannins. In vitro evaluations demonstrated effects of tanniferous plant extracts on the larval migration, larval artificial exsheathment, adult motility inhibition and egg hatching of H. contortus (Alonso-Díaz et al ., 2008; Moreno-Gonzalo et al ., 2013 a ; Naumann et al ., 2014). The use of polyvinylpolypyrrolidone (PVPP), an inhibitor of tannins, confirmed that this metabolite is responsible for the anthelmintic activity of the tanniferous plants (Alonso-Díaz et al ., 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Goats and sheep are infected with the same GIN species, mainly Haemonchus contortus , Trichostrongylus axei, Teladorsagia circumcincta (abomasum), T. colubriformis , Strongyloides papillosus, Nematodirus spp. (small intestine), Oesophagostomum columbianum and O. venulosum (large intestine) (Hoste et al ., 2010; Bentounsi et al ., 2012; Moreno-Gonzalo et al ., 2013 a ). The nematode of major concern is H. contortus , a highly pathogenic parasite, because its blood-sucking feeding habits cause anemia, submandibular edema and lethargy.…”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic activity of plants against gastrointestinal nematodes of goats: a review

et al. 2019

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The gastrointestinal nematodes (GIN) stand out as an important cause of disease in small ruminant, especially on goat farm. Widespread resistance to synthetic anthelminthics has stimulated the research for alternative strategies of parasite control, including the use of medicinal plants. The present work summarizes the in vitro and in vivo studies of plants with activity against GIN of goats, focusing on the description of chemical constituents related to this effect. This review retrieved 56 scientific articles from 2008 to 2018 describing more than 100 different plant species. The most frequently investigated family was Fabaceae (30.7%). Most in vitro studies on the activity of plant extracts and fractions were carried out with of free-living stages nematodes. In vivo studies were conducted mainly with the use of plants in animal feed and generally showed lower effectiveness compared to in vitro assays. The main plant secondary metabolites associated with anthelmintic effect are condensed tannins, saponin and flavonoids. However, the studies with compounds isolated from plants and elucidation of their mechanisms of action are scarce. Herbal medicines are thought to be promising sources for the development of effective anthelmintic agents.

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“…imperati stolon extract, demonstrating the difference between these extracts (Table 2). Extracts of several plant species are rich in phenolic compounds that inhibit nematode exsheatment [32, 33]. However, few studies have reported different activities among parts of the same plant [34].…”

Section: Resultsmentioning

confidence: 99%

Antiparasitic activities of hydroethanolic extracts of Ipomoea imperati (Vahl) Griseb. (Convolvulaceae)

et al. 2019

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Ipomoea imperati is widely used in tropical areas to treat several pathological conditions. The effect of this plant against parasitic species has not been investigated even being used for this purpose in the Brazilian northeastern. This study aimed to evaluate the anthelmintic and acaricide potential of a hydroethanolic extract of I. imperati leaves and stolons. I. imperati leaves and stolons were crushed and subjected to maceration in ethanol 70% (v/v), after which the solvent was removed using a rotary evaporator. The chromatographic profile of the extract was obtained by UV Spectrum high-performance liquid chromatography and compounds were identified by liquid chromatography/electrospray ionization tandem mass spectrometry. Identification of the compounds present in the extract was achieved by comparing their retention times and UV spectra with data in the literature. Anthelmintic activity was evaluated by larval exsheathment inhibition assays using Haemonchus contortus larvae and five concentrations of each extract ranging from 0.07 to 1.2 mg/mL. Acaricide activity was evaluated via larval immersion of Rhipicephalus microplus in eight concentrations of each extract ranging from 5.0 to 25.0 mg/mL. Live and dead larvae were counted after 24 hours. The median inhibitory concentration (IC50) for H. contortus larvae and the median lethal concentration (LC50) for R. microplus larvae were calculated. Twelve compounds were observed in the hydroethanolic extract of leaves, with a predominance of the aglycone form of flavonoids and tannins. This extract was effective against H. contortus larvae, presenting an average inhibitory concentration of 0.22 mg/mL, but showed no activity toward R. microplus larvae. The stolon hydroethanolic extract presented 11 compounds, with phenolic acids and glycosylated flavonoids prevailing. This extract showed low activity on R. microplus and no effect on inhibiting H. contortus larval exsheathment at the concentrations tested. This study is the first to assess the anthelmintic and acaricidal activities of I. imperati. Data reported confirm promising potential of I. imperati leaves hydroethanolic extract against H. contortus. This effect could be due to its secondary compounds presents in this extract, such as procyanidin, kaempferol, isoquercitrin and rutin.

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In vitro effect of heather (Ericaceae) extracts on different development stages of Teladorsagia circumcincta and Haemonchus contortus

Abstract: El artículo seleccionado no se encuentra disponible por ahora a texto completo por no haber sido facilitado todavía por el investigador a cargo del archivo del mismo.

Cited by 19 publications

References 43 publications

Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock

Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock

Anthelmintic activity of plants against gastrointestinal nematodes of goats: a review

Antiparasitic activities of hydroethanolic extracts of Ipomoea imperati (Vahl) Griseb. (Convolvulaceae)

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