In vitro dissolution of piroxicam capsules

Abstract

The in vitro dissolution rates of 10- and 20-mg piroxicam capsules from different suppliers in the U.K. were measured in simulated gastric fluid using rotating basket apparatus. Seven brands were tested and all were found to be satisfactory with at least 75% dissolution in 45 min.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Piroxicam

“…The dissolution studies were performed for different piroxicam capsules (10 and 20 mg) marketed in UK using the basket method and simulated gastric fluid (SIF) as a dissolution medium. Seven drug products were able to meet the specification of not less than 75% dissolved within 45 min …”