In vitro degradation behavior and cytocompatibility of biodegradable AZ31 alloy with PEO/HT composite coating

Tian, Peng; Liu, Xuanyong; Ding, Chuanxian

doi:10.1016/j.colsurfb.2015.02.011

Cited by 47 publications

(25 citation statements)

References 43 publications

(46 reference statements)

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“…The AZ31 sample coated with HA for 400 V and 40 min exhibited the highest corrosion resistance . The properties of MAO‐treated surfaces can be enhanced with pretreatments, posttreatments, or if used with a combination of other coating methods . Corrosion resistance and bioactivity of Mg alloy AZ31 were improved by hydrothermally treating the MAO‐treated surface.…”

Section: Coating Techniques Applied For Mg Alloysmentioning

confidence: 99%

The current trends of Mg alloys in biomedical applications—A review

2018

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Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. The hurdle in the extensive use of Mg implants is its fast degradation rate, which consequently reduces the mechanical strength to support the implant site. Alloy development, surface treatment, and design modification of implants are the routes that can lead to the improved corrosion resistance of Mg implants and extensive research is going on in all three directions. In this review, the recent trends in the alloying and surface treatment of Mg have been discussed in detail. Additionally, the recent progress in the use of computational models to analyze Mg bioimplants has been given special consideration.

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Section: Coating Techniques Applied For Mg Alloysmentioning

confidence: 99%

The current trends of Mg alloys in biomedical applications—A review

2018

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“…More seriously, the loss of mechanical strength might result in the failure of implantation. Surface modification is one of the most effective methods to enhance the corrosion resistance of Mg alloys, including hydrothermal treatment 6 – 8 , plasma electrolytic oxidation (PEO) 9 – 14 , electron beam treatments 15 , ion implantation 16 , apatite coating 11 , and organic polymer coating 12 , 17 , 18 etc. PEO as one of the most commonly studied methods can produce a highly adherent ceramic oxide coating, endowing Mg alloys an obviously improved corrosion resistance.…”

Section: Introductionmentioning

confidence: 99%

Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability

Peng

Wang

Tian

et al. 2017

Sci Rep

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In recent years, magnesium (Mg) alloys show a promising application in clinic as degradable biomaterials. Nevertheless, the poor corrosion resistance of Mg alloys is the main obstacle to their clinical application. Here we successfully seal the pores of plasma electrolytic oxidation (PEO) coating on AZ31 with Mg-Al layered double hydroxide (LDH) via hydrothermal treatment. PEO/LDH composite coating possess a two layer structure, an inner layer made up of PEO coating (~5 μm) and an outer layer of Mg-Al LDH (~2 μm). Electrochemical and hydrogen evolution tests suggest preferable corrosion resistance of the PEO/LDH coating. Cytotoxicity, cell adhesion, live/dead staining and proliferation data of rat bone marrow stem cells (rBMSCs) demonstrate that PEO/LDH coating remarkably enhance the cytocompatibility of the substrate, indicating a potential application in orthopedic surgeries. In addition, hemolysis rate (HR) test shows that the HR value of PEO/LDH coating is 1.10 ± 0.47%, fulfilling the request of clinical application. More importantly, the structure of Mg-Al LDH on the top of PEO coating shows excellent drug delivery ability.

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“…20 Furthermore, the huge difference in effective interface surface area between colloids and dense monolithic structures, ranging from several 100 m² down to below 1 mm², hinders a technological transfer of the individual findings. 3 In the present study, we propose plasma enhanced chemical vapor deposition (PE-CVD) as a superior technique for the deposition of SiO x . The SiO x interlayer serves as an interfacial adhesion promoter for organosilane coupling agents on densely sintered α-alumina for the use in biomaterial applications.…”

Section: Introductionmentioning

confidence: 99%

Plasma-Enhanced Chemical Vapor Deposition (PE-CVD) yields better Hydrolytical Stability of Biocompatible SiOx Thin Films on Implant Alumina Ceramics compared to Rapid Thermal Evaporation Physical Vapor Deposition (PVD)

Böke

Giner

Keller

et al. 2016

ACS Appl. Mater. Interfaces

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Densely sintered aluminum oxide (α-Al2O3) is chemically and biologically inert. To improve the interaction with biomolecules and cells, its surface has to be modified prior to use in biomedical applications. In this study, we compared two deposition techniques for adhesion promoting SiOx films to facilitate the coupling of stable organosilane monolayers on monolithic α-alumina; physical vapor deposition (PVD) by thermal evaporation and plasma enhanced chemical vapor deposition (PE-CVD). We also investigated the influence of etching on the formation of silanol surface groups using hydrogen peroxide and sulfuric acid solutions. The film characteristics, that is, surface morphology and surface chemistry, as well as the film stability and its adhesion properties under accelerated aging conditions were characterized by means of X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), inductively coupled plasma-optical emission spectroscopy (ICP-OES), and tensile strength tests. Differences in surface functionalization were investigated via two model organosilanes as well as the cell-cytotoxicity and viability on murine fibroblasts and human mesenchymal stromal cells (hMSC). We found that both SiOx interfaces did not affect the cell viability of both cell types. No significant differences between both films with regard to their interfacial tensile strength were detected, although failure mode analyses revealed a higher interfacial stability of the PE-CVD films compared to the PVD films. Twenty-eight day exposure to simulated body fluid (SBF) at 37 °C revealed a partial delamination of the thermally deposited PVD films whereas the PE-CVD films stayed largely intact. SiOx layers deposited by both PVD and PE-CVD may thus serve as viable adhesion-promoters for subsequent organosilane coupling agent binding to α-alumina. However, PE-CVD appears to be favorable for long-term direct film exposure to aqueous solutions.

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In vitro degradation behavior and cytocompatibility of biodegradable AZ31 alloy with PEO/HT composite coating

Cited by 47 publications

References 43 publications

The current trends of Mg alloys in biomedical applications—A review

The current trends of Mg alloys in biomedical applications—A review

Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability

Plasma-Enhanced Chemical Vapor Deposition (PE-CVD) yields better Hydrolytical Stability of Biocompatible SiOx Thin Films on Implant Alumina Ceramics compared to Rapid Thermal Evaporation Physical Vapor Deposition (PVD)

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