In Vitro Cytotoxic Activities of 2-Alkyl-4,6-diheteroalkyl-1,3,5-triazines:  New Molecules in Anticancer Research

Abstract

The cytotoxic activities of new 2-alkyl-4,6-dihetero-(N,O)alkyl-1,3,5-triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

“…The white precipitate was filtered and recrystallized from ethanol/water to obtain the desired products. (15 (16 (19). The product was obtained as a white solid, 0.67 g (82.0%) yield; mp: 132-134 °C; IR (KBr): 3571-2853 (br, OH, acid), 3316 (NH, amine), 1721 (CO, acid) cm (20).…”

“…1,3,5-triazine derivatives are an important class of small molecules with anti-cancer [11][12][13][14][15][16] and anti-viral activity, among others [17]. These compounds are known to be VLA-4 integrin antagonists, anti-inflammatory agents [18], sorbitol dehydrogenase inhibitors [19], estrogen receptor modulators [20], potential anti-trypanosomal drugs [21], antimalarial agents [22][23][24][25][26][27][28][29], hypolipidemic agents, [30] and antimicrobial agents [31][32][33].…”

Synthesis, Structural Elucidation and Anti-Microbial Screening of Benzimidazole Incorporated S-Triazinyl Derivatives

“…During the past few decades, 1,3,5-triazines have been grabbing the attention of the synthetic chemists for their wide gamut of biological activities, such as antimicrobial 7,8 , antiprotozoal 9 , anticancer 10 , antimalarial 11 and antiviral 12 activity.…”

Design, synthesis and characterization of [1,3,4]thiadiazolo- and [1,2,4]oxadiazolo- substituted 2,4-dicyclopropylamino-6-phenoxy-s-triazines

“…1,3,5-Triazine is an important heterocycle and has gained much synthetic popularity due to its broad spectrum of biological properties such as antimicrobial, 1 anticancer, 1 antimalarial, 1 antiviral, 1 antimycobacterial, 1 antibacterial, 1 antiprotozoal, 2 antifungal, 3 anti-trypanosomal, 4 VLA-4 integrin antagonists, 5 cytotoxic, 6 herbicidal, 7 anticonvulsant, 8 anti-inflammatory, 8 analgesic, 9 acetylcholinesterase inhibitors, 10 antiasthamatic 11 and dihydrofolate reductase inhibitors. 12 Recent studies, based on the s-triazine scaffold showing anti-tumour 13 and anti-HIV 14 activity have led these to be considered as most promising molecule to be employed as lead structures in the discovery of newer medicinally potent chemotherapeutic agents.…”