In vitro corrosion behaviour and osteoblast response of thermally oxidised Ti6Al4V alloy

García-Alonso, M. C.; Saldaña, Laura; Vallés, Gema; González-Carrasco, José Luis; González-Cabrero, J; Martı́nez, Marı́a Eugenia; Gil-Garay, E.; Munuera, L.

doi:10.1016/s0142-9612(02)00237-5

Cited by 167 publications

(91 citation statements)

References 18 publications

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“…[8,37] The outer circuit represents a pre-existing oxide layer of steel, whereas the inner circuit is related to an outer oxide layer. [37] This circuit was also suggested by Garcia-Alonso [52] with R 1 and C 1 representing the oxide layer and R 2 and C 2 representing the passive film of Ti6Al4V, resulting in two determined time constants. The same circuit was also used to describe self-assembled monolayers of modified alkanethiols.…”

Section: Different Equivalent Circuitsmentioning

confidence: 79%

Biomaterial Interface Investigated by Electrochemical Impedance Spectroscopy

2008

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Electrochemical impedance spectroscopyElectrochemical impedance spectroscopy is an easy applicable sensitive technique. It is used to get information about the adsorption behaviour and the interactions of biomolecules with the electrode surface in a short measurement duration. Electrochemical processes can be modelled by an equivalent circuit and various parameters reflecting certain properties of the interface can be determined. The electrochemical properties of the interface are influenced by proteins and cells adsorbing at the surface. Different modified surfaces can be analyzed before, during, and after cell contact, respectively. Applying bias potentials also changes the behaviour of attaching cells and proteins. Changes in the medium composition have an influence on the electrochemically detectable surface properties.Biosensors are developed consecutively to detect biomolecules. Enzymes, lipids and membranes can be analyzed and the adsorption behaviour of DNA and antigens at modified electrode surfaces can be determined. Different technologies using microchips were constructed to allow a fast screening of electrochemical properties and discrimination of biological molecules or cells. ApplicationElectrochemical impedance spectroscopy serves not only for determination of the capacity of new battery materials or corrosion behaviour and long term stability of diverse alloys and oxide layers, it can also be used to gain information about biomolecules. The adsorption behaviour of cells [1][2][3] and proteins, [4] the amount of adsorbed proteins, [4][5][6][7] surface charge densities [4][5][6] and adsorption coefficients [5] can be determined. Interactions of implant surfaces with biological devices, changes in the polarizability of functional groups, the transport of ions or dipoles through polymer layers and mineralization processes, for instance of bone tissue can be assessed. The change of the Gibbs free energy and the entropy due to protein binding to the surface can be calculated [4,6,8] and the affinity of biomolecules to the surface can be estimated. [4] Electrochemical techniques are introduced as biosensors. Antigens, ssDNA or enzymes are immobilized at the surface and according antibodies, DNA and distinct proteins can be ADVANCED ENGINEERING MATERIALS 2008, 10, No. 10

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Section: Different Equivalent Circuitsmentioning

confidence: 79%

Biomaterial Interface Investigated by Electrochemical Impedance Spectroscopy

2008

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“…Thermal oxidation of Ti64 in a furnace operating at 500-700 °C in air results in the formation of an outer layer of rutile that increases the adhesion rates of bone-forming cells to the alloy [2,4,8]. Unlike thermal treatment in air, which only marginally modifies surface roughness, LP treatment generates a wavy surface at a scale that can be recognized by hOBs and hMSCs [24].…”

Section: Discussionmentioning

confidence: 99%

On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing

et al. 2016

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We investigated a Ti6Al4V alloy modified by means of laser peening in the absence of sacrificial coatings. As a consequence of the temperature rise during laser focusing, melting and ablation generated an undulated surface that exhibits an important increase in the content of titanium oxides and OH− ions. Human mesenchymal stem cells and osteoblasts cultured on the oxidized alloy develop noticeable filopodia and lamellipodia. Their paxillin-stained focal adhesions are smaller than in cells attached to the untreated alloy and exhibit a marked loss of colocalization with the ends of actin stress fibers. An important imbalance of phosphorylation and/or dephosphorylation of the focal adhesion kinase is detected in cells grown on the oxidized alloy. Although these mechanisms of adhesion are deeply altered, the surface treatment does not affect cell attachment or proliferation rates on the alloy. Human mesenchymal stem cells cultured on the treated alloy in media containing osteogenic inducers differentiate towards the osteoblastic phenotype to a higher extent than those on the untreated surface. Also, the specific functions of human osteoblasts cultured on these media are enhanced on the treated alloy. In summary, laser peening tailors the Ti6Al4V surface to yield an oxidized layer with increased roughness that allows the colonization and activities of bone-lineage cells.

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“…Titanium dioxide (TiO 2 ) is a semiconducting material which may be used in a wide variety of technology applications such as temperature sensor, photocatalysis, electrolyte in solar cells, gas sensor, white pigment, corrosion protective coating, and optical coating, in memory devices, and as anode material Li batteries [2,3,4,5]. TiO 2 exists in three common modifications: anatase (tetragonal), rutile (tetragonal), and brookite (orthorhombic).…”

Section: Introductionmentioning

confidence: 99%

Study of Cavitation Erosion Experiments on Thermally Oxidized Rutile Phase TiO<SUB>2</SUB> Films on Stainless Steel

Nebatti¹,

Pflitsch²,

Brors³

et al. 2017

MATERIALS

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A technique to deposit titanium films with rutile-TiO 2 layer at the top was carried out in two steps: the deposition of titanium by means of cathodic vacuum arc (CVA) followed by a thermal oxidation technique was investigated. As a result, well adhering rutile films occurred in the near surface region. The uncoated and coated substrates were investigated using X-ray diffraction (XRD) and energy dispersive x-ray spectroscopy (EDX). The presence of rutile phase titanium dioxide and titanium metal was confirmed by XRD. Cavitation erosion was used to investigate the protective adhesion properties of these coatings. Cavitation erosion tests confirmed that rutile TiO 2 films with a Ti inter layer adhere well to stainless steel substrates and protect the substrate from erosion.

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In vitro corrosion behaviour and osteoblast response of thermally oxidised Ti6Al4V alloy

Cited by 167 publications

References 18 publications

Biomaterial Interface Investigated by Electrochemical Impedance Spectroscopy

Biomaterial Interface Investigated by Electrochemical Impedance Spectroscopy

On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing

Study of Cavitation Erosion Experiments on Thermally Oxidized Rutile Phase TiO<SUB>2</SUB> Films on Stainless Steel

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