In vitro antiviral activity against Zika virus from a natural product of the Brazilian red seaweed Bryothamnion triquetrum

Cirne-Santos, Cláudio César; Barros, Caroline de Souza; Rabelo, Vitor Won‐Held; Esteves, Priscilla O.; Gomes, Max Willian Lisboa; Teixeira, Valéria Laneuville; de, Izabel C N

doi:10.4149/av_2021_406

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…The reported NPs mostly act at the stages of viral adsorption and internalization, and they present a virucidal effect. The reviewed data demonstrate their potential for developing new anti-ZIKV agents and also highlight the importance of additional studies addressing the molecular mechanisms of action of promising compounds such as epigallocatechin gallate (SI ≥ 25,000) [ 101 ], anisomycin (SI ≥ 11,900) [ 145 ], dolastane (SI = 1246) [ 153 ], and myricetin (SI ≥ 862) [ 101 ], among others. Some of the active compounds against Zika virus have been shown by in silico and in vitro assays to be active against other clinically important viruses and are promising candidates for further investigations aiming to develop broad-spectrum antivirus agents.…”

Section: Discussionmentioning

confidence: 99%

“…The dichloromethane extract of the red seaweed Bryotamnion triquetrum showed inhibitory activity on the ZIKV replication in Vero cells with values of CC 50 = 400.00 ± 13.50 µg/mL, EC 50 = 1.38 µg/mL and SI = 289.85. The investigation of its mechanism of action revealed a moderate virucidal effect and moderate inhibition at the attachment stage of the virus in the host cell [ 153 ].…”

Section: Nps With Potential Anti-zikv Activitymentioning

confidence: 99%

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Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

Pereira

Santos

Campana

et al. 2023

Viruses

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Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and derivatives published from 1997 to 2022, which were carried out with NPs obtained from plants (82.4%) or semisynthetic/synthetic derivatives, fungi (3.1%), bacteria (7.6%), animals (1.2%) and marine organisms (1.9%) along with miscellaneous compounds (3.8%). Classes of NPs reported to present anti-ZIKV activity include polyphenols, triterpenes, alkaloids, and steroids, among others. The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC50/EC50), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from Streptomyces bacteria, dolastane (SI = 1246) isolated from the marine seaweed Canistrocarpus cervicorni, and the flavonol myricetin (SI ≥ 862). NPs mostly act at the stages of viral adsorption and internalization in addition to presenting virucidal effect. The data demonstrate the potential of NPs for developing new anti-ZIKV agents and highlight the lack of studies addressing their molecular mechanisms of action and pre-clinical studies of efficacy and safety in animal models. To the best of our knowledge, none of the active compounds has been submitted to clinical studies.

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Section: Discussionmentioning

confidence: 99%

Section: Nps With Potential Anti-zikv Activitymentioning

confidence: 99%

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

Pereira

Santos

Campana

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Yuan et al have found that cyclodepsipeptides (CDPs), extracted from the sea sponge-associated fungus Beauveria feline , exhibit anti-ZIKV activity [ 29 ]. In Vero cells, the dichloromethane extract of the red seaweed Bryotamnion triquetrum inhibits ZIKV replication [ 30 ]. Above all, marine natural products are crucial for the development of new antiviral drugs, especially for neglected diseases.…”

Section: Introductionmentioning

confidence: 99%

A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase

Zhang,

Liang,

Zhang

et al. 2024

Molecules

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The Zika virus (ZIKV) is a mosquito-borne virus that already poses a danger to worldwide human health. Patients infected with ZIKV generally have mild symptoms like a low-grade fever and joint pain. However, severe symptoms can also occur, such as Guillain-Barré syndrome, neuropathy, and myelitis. Pregnant women infected with ZIKV may also cause microcephaly in newborns. To date, we still lack conventional antiviral drugs to treat ZIKV infections. Marine natural products have novel structures and diverse biological activities. They have been discovered to have antibacterial, antiviral, anticancer, and other therapeutic effects. Therefore, marine products are important resources for compounds for innovative medicines. In this study, we identified a marine natural product, harzianopyridone (HAR), that could inhibit ZIKV replication with EC50 values from 0.46 to 2.63 µM while not showing obvious cytotoxicity in multiple cellular models (CC50 > 45 µM). Further, it also reduced the expression of viral proteins and protected cells from viral infection. More importantly, we found that HAR directly bound to the ZIKV RNA-dependent RNA polymerase (RdRp) and suppressed its polymerase activity. Collectively, our findings provide HAR as an option for the development of anti-ZIKV drugs.

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Synthesis and virucide activity on zika virus of 1,2,3-triazole-containing vanillin derivatives

et al. 2023

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In vitro antiviral activity against Zika virus from a natural product of the Brazilian red seaweed Bryothamnion triquetrum

Cited by 5 publications

References 37 publications

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase

Synthesis and virucide activity on zika virus of 1,2,3-triazole-containing vanillin derivatives

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