2015
DOI: 10.1590/1516-635x1703275-280
|View full text |Cite
|
Sign up to set email alerts
|

In-Vitro Antiviral Activities of Extracts of Plants of The Brazilian Cerrado against the Avian Metapneumovirus (aMPV)

Abstract: Avian metapneumovirus (aMPV) is a negative-sense single-stranded RNA enveloped virus of the Metapneumovirus genus belonging to the Paramyxoviridae family. This virus may cause significant economic losses to the poultry industry, despite vaccination, which is the main tool for controlling and preventing aMPV. The aim of this study was to evaluate the antiviral activity of extracts of four different native plants of the Brazilian Cerrado against aMPV. The antiviral activity against aMPV was determined by titrati… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
27
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 35 publications
(27 citation statements)
references
References 17 publications
(16 reference statements)
0
27
0
Order By: Relevance
“…Ramalingam et al [28] reported that the ethanolic extracts of Andrographis paniculata have the highest antiviral inhibitory effects against dengue virus in Vero cells. The screening of plants as possible sources of antiviral agents has led to the discovery of potent inhibitors of in vitro viral replication, thereby increasing the probability of identifying new bioactive plant compounds [29]. These findings suggest the appropriate species and concentration of plant extract that could effectively inhibit PRRSV replication, with both T. triandra and C. sappan extracts being highly effective in inhibiting PRRSV infection in vitro by interfering with viral attachment and inhibiting viral replication and/or virus release, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…Ramalingam et al [28] reported that the ethanolic extracts of Andrographis paniculata have the highest antiviral inhibitory effects against dengue virus in Vero cells. The screening of plants as possible sources of antiviral agents has led to the discovery of potent inhibitors of in vitro viral replication, thereby increasing the probability of identifying new bioactive plant compounds [29]. These findings suggest the appropriate species and concentration of plant extract that could effectively inhibit PRRSV replication, with both T. triandra and C. sappan extracts being highly effective in inhibiting PRRSV infection in vitro by interfering with viral attachment and inhibiting viral replication and/or virus release, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…Post adsorption studies involved first infecting the cells with the HSV-1 virus followed an hour later by the addition of crude extracts of D. integrifolia. 20 From our results, we found that the methanol flower extract of D. integrifolia inhibited HSV-1 infection more strongly postadsorption than during other treatment durations. This may suggest that this extract may not prevent the entry of HSV-1 into the Vero cell, but it acts after the virus has already penetrated the cell.…”
Section: Discussionmentioning
confidence: 55%
“…To evaluate the mechanism of antiviral activity vis-à-vis the step of the viral cycle where replication of HSV-1 was inhibited, different treatment protocols were followed. 20,21 Pre-treatment studies involved treating the HSV-1 virus with each of the crude extracts of D. integrifolia before infecting the cells. 20 This was done to evaluate the virus inactivation capacity of these extracts.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Ten-fold serial dilutions of HSV-1 and virus-treated extracts of HSV-1 were prepared prior to the infection. The number of plaque-forming units was determined and a decrease of virus titer was calculated [19]:…”
Section: Infectious Virus Yield Reduction Assaymentioning
confidence: 99%