In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

Abstract

Magnetite functionalized nanoparticles with Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145 and HuTu80; Pd(L2)2 is found to be a promising pharmacological agent.

Synthesis, structure and in vitro anticancer, DNA binding and cleavage activity of palladium (II) complexes based on isatin thiosemicarbazone derivatives

“…This finding was further supported by the band at approximately 748 to 769 cm −1 for the metal complexes because of ν(C─S) . Thus, the IR spectral results for PdL1 to PdL6 provide strong evidence for the complexation of Schiff bases with metal ions in a tridentate mode as reported for similar structures …”

“…Similarity between the coordination chemistry of platinum(II) and palladium(II) compounds also supports the theory that palladium complexes can act successfully as anti‐tumour drugs . Thus, some palladium complexes with aromatic N‐containing Schiff bases have shown very promising anti‐tumour characteristics . With similar structural features, a study in 2015 investigated the interaction between isatin β‐thiosemicarbazone and calf thymus DNA (CT DNA) using UV–visible absorption and fluorescence spectroscopy, as well as viscosity measurements.…”

Design of a Thiosemicarbazide-Functionalized Calix[4]arene Ligand and Related Transition Metal Complexes: Synthesis, Characterization, and Biological Studies

“…The expected N–H bond stretching of the thiosemicarbazide group lies within the broad envelope of the peak centered at 3,437 cm −1 , which also contains the O–H stretching (Silverstein et al, 1991; Rastogi et al, 2002). The other bands, corresponding to C–H, C = C, and C–C vibrational modes of aromatic rings (Baldini et al, 2003; Hernández et al, 2016), are conserved in both 4 and L spectra.…”

Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

“…To our knowledge, there are very few examples in the references where the palladium thiosemicarbazone derivative showed better cytotoxicity than the platinum analogue. [22][23][24] In fact, this kind of response should not be that unusual in chelate complexes, based in the higher kinetic lability of the Pd(II) complexes 25 , which should endow the complex with a better interaction potential with DNA or other biological molecules usually overexpressed in the cancer cells.…”