In vitro antioxidant activity of methanolic extracts of Ageratum conyzoides and Ageratina adenophora leaves

Khazeo, P.; Mazumder, Muslek Uddin; Puro, K.; Jyrwa, Rosamund; Jamir, Nungshioba; Sailo, Lalzikpuii

doi:10.2991/msc-18.2018.27

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…In addition, oil extracts from A. adenophora showed antioxidant activity, with IC50 values of 8.3 and 4.2 µL, after being tested using the DPPH and β-carotene bleaching methods, respectively [ 22 ]. Lastly, methanolic extracts from A. adenophora showed significant DPPH activity as compared to the standard butylated hydroxyl toluene (IC50 for A. adenophora was 92.791, whereas that for butylated hydroxyl toluene was 68.043) [ 79 ]. Therefore, harnessing these extracts and secondary metabolites into antioxidant drugs or feed supplements to reduce the ROS damages induced by A. adenophora and other toxins could play an important role in reducing the toxicity of this plant as well utilizing the plant’s resources for the benefit of mankind.…”

Section: Pharmacological Applications Of a Adenophora And Potential Therapeutic Interventions Against Its Toxicitymentioning

confidence: 99%

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

Ren

Okyere

Wen

et al. 2021

IJMS

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Ageratina adenophora is one of the major invasive weeds that causes instability of the ecosystem. Research has reported that A. adenophora produces allelochemicals that inhibit the growth and development of food crops, and also contain some toxic compounds that cause toxicity to animals that consume it. Over the past decades, studies on the identification of major toxic compounds of A. adenophora and their toxic molecular mechanisms have been reported. In addition, weed control interventions, such as herbicides application, was employed to reduce the spread of A. adenophora. However, the development of therapeutic and prophylactic measures to treat the various A. adenophora—induced toxicities, such as hepatotoxicity, splenotoxicity and other related disorders, have not been established to date. The main toxic pathogenesis of A. adenophora is oxidative stress and inflammation. However, numerous studies have verified that some extracts and secondary metabolites isolated from A. adenophora possess anti-oxidation and anti-inflammation activities, which implies that these extracts can relieve toxicity and aid in the development of drug or feed supplements to treat poisoning-related disorders caused by A. adenophora. Furthermore, beneficial bacteria isolated from rumen microbes and A. adenophora can degrade major toxic compounds in A. adenophora so as to be developed into microbial feed additives to help ameliorate toxicity mediated by A. adenophora. This review presents an overview of the toxic mechanisms of A. adenophora, provides possible therapeutic strategies that are available to mitigate the toxicity of A. adenophora and introduces relevant information on identifying novel prophylactic and therapeutic measures against A. adenophora—induced toxicity.

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Section: Pharmacological Applications Of a Adenophora And Potential Therapeutic Interventions Against Its Toxicitymentioning

confidence: 99%

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

Ren

Okyere

Wen

et al. 2021

IJMS

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“…The plant originated in Mexico, although it can also be found in nations in South and Southeast Asia. Larvicidal 17 , antimicrobial 18 , anti-inflammatory 19 , antipyretic 20 , wound-healing 21 , antioxidant 22 , and analgesic 23 have been demonstrated. E. coli, Bacillus subtilis, S. aureus, K. pnuemoniae 24 , and Proteus mirabilis were effectively inhibited by A. adenophora 25 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity

Maheswari¹,

N²,

N³

et al. 2023

Orient. J. Chem

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Synthetic antibiotics have been successfully utilized for decades against pathogenic bacteria to control infectious diseases. However, the continuous and overuse has resulted in multidrug resistant (MDR) bacterial species. Further, the negative side effects caused by commercial antibiotics also hindered their usage. The phytochemicals produced by plants in response to adverse biotic and abiotic conditions possess significant pharmacological properties and can be an effective alternative to synthetic antibiotics. The phytochemicals of Ageratinaadenophora, served the role of reducing and stabilizing agent. Ageratinaadenophora mediated silver nanoparticles (Aa-AgNPs) were characterized using advanced spectroscopic instrumentation. The qualitative analysis by GC-MS showed Methyl ionone, 2(3H)-Naphthalenone, 4, 4a, 5, 6, 7, 8- hexahydro-4a,7,7-trimethyl-(R), Isolongifolone as the major compounds. The quantitative estimation showed leaves were rich in total phenol, flavonoids, alkaloids and tannins. The Aa-AgNPs were effective in inhibiting bacterial pathogens. Further, A.adenophora mediated nanoparticles possessed strong antioxidant activity.

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Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

et al. 2023

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The green synthesis of metallic nanoparticles has tremendous impacts in various fields as found in recent years due to their low cost, easy and environmentally friendly synthesis. In this article, we report a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using an aqueous Eupatorium adenophorum ( E. adenophorum ) leaf extract as a bioreductant. Interestingly, Fourier transform infrared (FTIR) spectroscopy analysis established that the E. adenophorum extract not only served as a bioreductant but also acted as a capping agent to stabilize the nanoparticles by functionalizing the surfaces. Various characterization techniques were adopted, such as X-ray powder diffraction (XRD), FTIR, ultraviolet–visible absorption (UV–Vis) spectroscopy, dynamic light scattering, scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX) to analyze the biosynthesized AgNPs. Biosynthesized nanoparticles were also explored for antioxidant, antibacterial and photocatalytic activities. The AgNPs showed improved free radical scavenging activity (IC 50 48.96 ± 0.84 µg/mL) and bacterial inhibitory effects against both gram-positive ( Staphylococcus aureus ; 64.5 µg/mL) and gram-negative ( Escherichia coli ; 82.5 µg/mL) bacteria. Photocatalytic investigation showed AgNPs were effective at degrading rhodamine dye (78.69% in 90 min) when exposed to sunlight. These findings collectively suggest that E. adenophorum AgNPs were successfully prepared without the involvement of any hazardous chemical and it may be an effective antibacterial, antioxidant and promising agent for the removal of hazardous dye from waste water produced by industrial dyeing processes.

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In vitro antioxidant activity of methanolic extracts of Ageratum conyzoides and Ageratina adenophora leaves

Cited by 3 publications

References 8 publications

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity

Green synthesis of silver nanoparticles using Eupatorium adenophorum leaf extract: characterizations, antioxidant, antibacterial and photocatalytic activities

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