In vitro antimicrobial activity of Wrightia tinctoria leaf extracts against skin microorganisms

In vitro antifungal activity of indirubin isolated from a South Indian ethnomedicinal plant Wrightia tinctoria R. Br.

“…Among them, Wrightia tinctoria (Apocynaceae family), an important ethnomedicinal plant, is widely used to treat skin diseases in folk medicine (Joshi et al, 1980;Nadkarni, 1976;Shah and Gopal, 1988). There have been few reports on antibacterial and antifungal activity of Wrightia tinctoria crude extracts (Anbuganapathi et al, 2002;Kannan et al, 2006) but in depth knowledge on the biological activity of its components is lacking. Indirubin, a flavonoid was isolated and identified from the leaves of Wrightia tinctoria (Muruganandam et al, 2000).…”

Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

“…It is the leaf extract of W. tinctoria which forms the major constituent in the Siddha preparation for the treatment of psoriasis. The experimental evidence of antimicrobial property has been produced in the laboratory against the skin microorganism supports the claims of the plants used in the cure of psoriasis in the Siddha system [85]. In vitro studies on the extracts from this species have shown a range of antimicrobial activities.…”

“…The leaves hold potent antimicrobial properties against dermatophytic microbes. Kannan et al screened different solvent extracts against skin bacteria and dermatophytes [85]. The methanol and ethanol extracts were found to be more active against studied bacteria (at MIC 0.5 mg/mL for Bacillus subtilis, Staphylococcus epidermidis and 0.25 mg/mL for Staphylococcus aureus) whereas, hexane extract found to be potent against dermatophytic fungi such as Trichophyton rubrum and Trichophyton tonsurans at 2 mg/mL [85].…”

“…Kannan et al screened different solvent extracts against skin bacteria and dermatophytes [85]. The methanol and ethanol extracts were found to be more active against studied bacteria (at MIC 0.5 mg/mL for Bacillus subtilis, Staphylococcus epidermidis and 0.25 mg/mL for Staphylococcus aureus) whereas, hexane extract found to be potent against dermatophytic fungi such as Trichophyton rubrum and Trichophyton tonsurans at 2 mg/mL [85]. Similarly, in another study, in vitro antibacterial activities of the petroleum ether, chloroform, methanol and water extracts of leaves of W. tinctoria were studied against Staphylococcus aureus (S. aureus) (Gram-positive) Escherichia coli (E. coli) (Gramnegative) as test organisms [86].…”

Phytochemical Screening and In vitro Antimicrobial Properties of Crude Leaf Extracts of Wrightia tinctoria R.Br.

“…Kannan et al, (2006) reported the antimicrobial activity of W.tinctoria hexane, methanol and ethanol leaf extracts against dermatophytes. Methanol and ethanol extracts showed antibacterial activity.…”