2021
DOI: 10.1590/1809-4392201904462
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Abstract: The biochemical defense mechanisms of amphibians involve cutaneous secretions of bioactive molecules with antimicrobial activity. This study evaluated the in vitro activity of methanolic extracts from cutaneous secretions of two amphibian species of the Bufonidae family, Rhaebo guttatus and Rhinella marina, in the control of the phytopathogens Fusarium udum, Fusarium solani, Colletotrichum truncatum, Aspergillus flavus, Rhizoctonia solani, Macrophomina phaseolina, and Calonectria pseudometrosideri. The R. gutt… Show more

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Cited by 1 publication
(3 citation statements)
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“…In Brazil, the most extensively studied amphibian-derived skin secretions are from Rhinella marina (R. marina; Cururu toad), which contains compounds, such as marinobufagin, telecinobufagin, bufalin, marinobufotoxin, cholesterol, dehydrobufotenine, and suberoyl arginine (2,22,23). A variety of biological effects have been attributed to the compounds in R. marina skin secretions extracts, including cytotoxic, immunomodulatory, antifungal, antimutagenic, and anti-plasmodial activities (9)(10)(11)(22)(23)(24)(25).…”
Section: Discussionmentioning
confidence: 99%
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“…In Brazil, the most extensively studied amphibian-derived skin secretions are from Rhinella marina (R. marina; Cururu toad), which contains compounds, such as marinobufagin, telecinobufagin, bufalin, marinobufotoxin, cholesterol, dehydrobufotenine, and suberoyl arginine (2,22,23). A variety of biological effects have been attributed to the compounds in R. marina skin secretions extracts, including cytotoxic, immunomodulatory, antifungal, antimutagenic, and anti-plasmodial activities (9)(10)(11)(22)(23)(24)(25).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to R. marina, another common frog species in Brazil is R. guttatus, particularly in the Amazon Basin; however the compounds in their skin secretions are poorly characterized (2,5). Some compounds were identified, such as N-methyl-5-hidroxytryptamine, bufotenine, dehydrobufotenine, 3β,16 β-dihydroxybufa-8 (14),20,22-trienolide, marinobufagin, and bufatrienolides (2,7,8), and biological effects have been reported in the literature, including cytotoxic, anti-plasmodial, fungicidal, hemolytic and antimutagenic activities (8)(9)(10)(11).…”
Section: Discussionmentioning
confidence: 99%
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