In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts

Rybalchenko, N.; Prykhodko, V.A.; Нагорна, С. С.; Volynets, N.N.; Остапчук, А. М.; Клочко, В.В.; Rybalchenko, T.V.; Avdeeva, L.V.

doi:10.1016/j.fitote.2009.10.007

Cited by 20 publications

(19 citation statements)

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“…Its shoots and leaves, dried or fresh, are utilized in sauces and teas [13, 14]. In the 1970s, the United Nations Food and Agriculture Organization (FAO) promoted the cultivation of B. pilosa in Africa because it is easy to grow, edible, palatable, and safe [15].…”

Section: Introductionmentioning

confidence: 99%

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Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

Bartolome

Villaseñor

Yang

2013

Evidence-Based Complementary and Alternative Medicine

212

220

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There are 230 to 240 known Bidens species. Among them, Bidens pilosa is a representative perennial herb, globally distributed across temperate and tropical regions. B. pilosa has been traditionally used in foods and medicines without obvious adverse effects. Despite significant progress in phytochemical and biological analyses of B. pilosa over the past few years, comprehensive and critical reviews of this plant are anachronistic or relatively limited in scope. The present review aims to summarize up-to-date information on the phytochemistry, pharmacology, and toxicology of B. pilosa from the literature. In addition to botanical studies and records of the traditional use of B. pilosa in over 40 diseases, scientific studies investigating the potential medicinal uses of this species and its constituent phytochemicals for a variety of disorders are presented and discussed. The structure, bioactivity, and likely mechanisms of action of B. pilosa and its phytochemicals are emphasized. Although some progress has been made, further rigorous efforts are required to investigate the individual compounds isolated from B. pilosa to understand and validate its traditional uses and develop clinical applications. The present review provides preliminary information and gives guidance for further basic and clinical research into this plant.

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Section: Introductionmentioning

confidence: 99%

“…It is frequently prepared as a dry powder, decoction, maceration or tincture [16]. Generally, this plant is applied as dry powder or tincture when used externally, and as a powder, maceration, or decoction when used as an internal remedy [14]. …”

Section: Introductionmentioning

confidence: 99%

Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

Bartolome

Villaseñor

Yang

2013

Evidence-Based Complementary and Alternative Medicine

212

220

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“…The main components of the tested essential oil are oxygenated monoterpenes, sesquiterpene hydrocarbons and monoterpene hydrocarbons. According to previous studies B. cernua herb oil was rich in polyacetylenes and especially 1-phenylhepta-1,3,5-triyn [3,4] that was absent in researched oil. The other compounds identified in the oil are in good accordance with data published for B. cernua [4].…”

Section: Identification Of Essential Oil Componentmentioning

confidence: 84%

“…Previous phytochemical reports on B. cernua have revealed the presence of secondary plant metabolites such as polyacetylenes, sesquiterpenes, essential oil and flavonoids [1][2][3][4][5]. In continuation of our interest in the phytochemistry of plants from genus Bidens growing in Poland we decided to carry out a phytochemical studies on the herb and flowers of B. cernua of Polish origin.…”

Section: Previous Studiesmentioning

confidence: 99%

Flavonoids and Essential Oil of Bidens cernua of Polish Origin and in Vitro Antimicrobial Activity of the Oil

Tomczykowa¹,

Leszczyńska²,

Kalemba³

2017

Rec.Nat.Prod.

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Phytochemical studies of the aerial parts of Bidens cernua L. led to the isolation of six flavonoids: luteolin (1), flavanomarein (2), tilianin (3), maritimetin (4), cynaroside (5) and cosmosiin (6). The quantitative analysis of flavonoids exhibited 0.81% contents of flavonoids in flowers and 1.62% in the herb counted as a hyperoside equivalent. Total Tannins Content showed the occurrence of 7.87% in flowers and 5.83% in the herb. The chemical composition of the essential oil obtained from the herb of B. cernua was evaluated in 92.2%, which corresponds to 99 compounds. Antimicrobial activity of the essential oil was evaluated on Gram-positive, Gram-negative bacteria and fungi. The oil exhibited a strong antibacterial and antifungal activity, especially against Gram-positive bacterial strains. This is the first time the aforementioned compound (3) has been isolated from B. cernua. Keywords: Bidens cernua;Asteraceae; phytochemical analysis; flavonoids; essential oil; antimicrobial activity. © 2017 ACG Publications. All rights reserved. Plant Source Previous StudiesPrevious phytochemical reports on B. cernua have revealed the presence of secondary plant metabolites such as polyacetylenes, sesquiterpenes, essential oil and flavonoids [1][2][3][4][5]. In continuation of our interest in the phytochemistry of plants from genus Bidens growing in Poland we decided to carry out a phytochemical studies on the herb and flowers of B. cernua of Polish origin. Present StudyTo isolate the flavonoid compounds, the diethyl ether, ethyl acetate and butanolic extracts were subjected to subsequent column chromatography on polyamide as stationary phase with eluting solvent systems of increasing polarity. As a result of series isolation procedures and purification on Sephadex LH-20, compounds 1-6 were obtained. The known isolates were confirmed as luteolin (1) [6], flavanomarein (isookanin 7-O-β-D-glucopyranoside) (2) [7], maritimetin (4) [8], cynaroside (luteolin 7-O-β-D-glucopyranoside) (5) [6] and cosmosiin (apigenin 7-O-β-D-glucopyranoside) (6) [8] by the comparison of reported spectral and physical data. To the best of authors knowledge, this is the first report on the isolation of tilianin (acacetin 7-O-β-D-glucopyranoside) (3) from B. cernua.

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“…According to the comprehensive review of Marles and Farnsworth (), more than 1,200 species have been used ethnopharmacologically or experimentally to treat symptoms of diabetes. Like many other Asteraceae plants, Bidens species are used as antidiabetic in different countries (Andrade‐Cetto & Heinrich, ; Korkmaz, Mumcu, & Alkan, ; Marles & Farnworth, ; Morton, ; Rahman, Bajpai, Dung, & Kang, ; Rybalchenko et al, ; Yang, ). Additionally, B. cernua L. has been used for treatment of metabolic disturbances, diathesis, skin diseases, scrofulous, seborrhea, psoriasis, neurodermatites, wounds, neoplasms, and also as a diuretic and sudorific remedy in folk medicine (Chien et al, ).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antioxidant and antidiabetic activity studies on standardized extracts of twoBidensspecies

Icoz¹,

Orhan

Altun

et al. 2017

J Food Biochem

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Aim of this study is to evaluate the in vivo and in vitro antidiabetic and antioxidant profile of standardized ethanol extracts of Bidens cernua L. var. radiata and B. frondosa L. Acute hypoglycemic activity of extracts were investigated on normoglycemic, glucose loaded and streptozotocin‐induced diabetic rats. Sub‐acute antidiabetic effect was investigated during the 8 days experiment. Both the extracts exhibited promising and significant hypoglycaemic effect in all tested in vivo models. Acute antidiabetic effect of B. cernua and B. frondosa were found as 40% and 42% at 500 mg/kg dose, respectively. α‐Glucosidase and α‐amylase inhibitory activity of the extracts were also determined and both of the extracts inhibited α‐glucosidase enzyme strongly (64.29–75.22% at 2 mg/mL). Conversely, in vitro antioxidant activity and total flavonoid content of extracts were measured. The extracts were standardized by RP‐HPLC‐DAD on the basis of cynaroside and chlorogenic acid as markers. Practical applications Bidens species have been used both as food and traditional medicine. In some countries, young leaves of Bidens species are added to salads, soups, and young shoot tips are used to make a tea. Our results revealed that Bidens species standardized by cynaroside and chlorogenic acid had a significant effect on regulation of blood glucose levels. It can be concluded that the tested Bidens species, that were found to be rich in flavonoid and phenolic compounds, might be beneficial for diabetic patients.

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In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts

Cited by 20 publications

References 10 publications

Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

Flavonoids and Essential Oil of Bidens cernua of Polish Origin and in Vitro Antimicrobial Activity of the Oil

In vitro and in vivo antioxidant and antidiabetic activity studies on standardized extracts of twoBidensspecies

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