In-vitro and in-vivo study of superabsorbent PVA/Starch/g-C3N4/Ag@TiO2 NPs hydrogel membranes for wound dressing

Ahmed, Arooj; Niazi, Muhammad Bilal Khan; Jahan, Zaib; Ahmad, Tahir; Hussain, Arshad; Pervaiz, Erum; Janjua, Hussnain Ahmed; Hussain, Zakir

doi:10.1016/j.eurpolymj.2020.109650

Cited by 87 publications

(46 citation statements)

References 66 publications

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“…The presence of a trace amount of uronic acid and protein, the pH of GO was found to be acidic in nature 9 which would be very much effective for wound healing. 17 Mitra et al 15 already reported the stability of GO in acidic pH (3)(4) and degradability at basic pH (6)(7)(8). Hence, the degradation of GO might be facilitated due to alkaline environment at the wound site, 18 which could be a good agreement with biodegradability and release of drug molecules from the wound care product at the affected site.…”

Section: Introductionmentioning

confidence: 89%

“…3 Wound repairing is the most complex phenomenon in the human body. 4 In recent years, broad ranges of polymeric materials have been proposed to design wound dressing materials, which can be divided into the natural and synthetic polymeric dressing. Ideal dressing materials should be nontoxic, biodegradable, porous in nature, permeable to oxygen, which induces angiogenesis and ultimately provides mechanical protection from external injury.…”

Section: Introductionmentioning

confidence: 99%

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Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool

Das

et al. 2020

J of Applied Polymer Sci

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The present study focuses on development of HPMC K100M reinforced antimicrobial loaded spongy biodegradable wound dressing scaffold by blending gum odina (GO) and gelatin (G) which has not been explored so far. All the prepared formulations by varying GO‐HPMC K100M: G are subjected to physicochemical evaluations (visual appearance, swelling study, biodegradability, drug loading, and drug release). F3B (GO‐HPMC K100M: G = 1:1, blank) and F3D (GO‐HPMC K100M: G = 1:1, drug loaded) are optimized and selected for further evaluations. Controlled degradation and sustained release of impregnated drug molecules from F3D may influence the antimicrobial efficacy. A satisfactory result of protein adsorption on the surface of F3B and F3D (almost 24%) can be an important event for being a biomaterial. The safe value of hemolytic potentiality (approximately 4%) may consider as biocompatible in nature. Furthermore, upon other characterizations F3B and F3D can be considered as an excellent potential candidate for biomedical application.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool

Das

et al. 2020

J of Applied Polymer Sci

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“…Similar trends were reported by Lin et al [58], who informed that a starch/PVA/TiO 2 (0.03% w/w) hybrid composite exhibited bacteriostatic activity against E. coli and Listeria monocytogenes, but the effect was dependent on the strain and TiO 2 content. Likewise, Ahmed et al [56] found that the addition of TiO 2 nanoparticles in a PVA-starch-g-C 3 -N 4 -Ag hydrogel membrane enhanced the antibacterial activity against E. coli (inhibition zone of 37.33 mm) and S. aureus (inhibition zone of 33.25 mm).…”

Section: Evaporative Casting/membranementioning

confidence: 95%

“…Additionally, Ahmed et al [56] evaluated in vivo the wound-dressing properties of a PVA-starch-g-C 3 -N 4 -Ag-TiO 2 hydrogel membrane in an open excision-type wound-healing study in adult female Albino mice. They found that hybrid membranes had better-wound healing (reduction wound area of 97%) efficiency than cotton gauze (reduction wound area of 19.5%) or untreated (reduction wound area of 7.4%) groups after seven days of evolution.…”

Section: Other Applications Of Starch-tio 2 Hybrid Materialsmentioning

confidence: 99%

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

et al. 2020

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In recent years, a strong interest has emerged in polysaccharide-hybrid composites and their potential applications, which have interesting functional and technological properties. This review summarizes and discusses the reported advantages and limitations of the functionalization of conventional and nonconventional polysaccharides by adding TiO2 nanoparticles as a reinforcement agent. Their effects on the mechanical, thermal, and UV-barrier properties as well as their water-resistance are discussed. In general, the polysaccharide–TiO2 hybrid materials showed improved physicochemical properties in a TiO2 content-dependent response. It showed antimicrobial activity against bacteria (gram-negative and gram-positive), yeasts, and molds with enhanced UV-protective effects for food and non-food packaging purposes. The reported applications of functionalized polysaccharide–TiO2 composites include photocatalysts (dye removal from aqueous media and water purification), biomedical (wound-healing material, drug delivery systems, biosensor, and tissue engineering), food preservation (fruits and meat), cosmetics (sunscreen and bleaching tooth treatment), textile (cotton fabric self-cleaning), and dye-sensitized solar cells. Furthermore, the polysaccharide–TiO2 showed high biocompatibility without adverse effects on different cell lines, indicating that their use in food, pharmaceutical, and biomedical applications is safe. However, it is necessary to evaluate the structural changes promoted by the storage conditions (time and temperature) on the physicochemical properties of polysaccharide–TiO2 hybrid composites to guarantee their stability during a determined time.

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“…Antibacterial and antioxidative bio-based nanocomposite hydrogels that can accelerate the wound healing process are in heavy demand for soft tissue engineering applications. Previous studies have reported the use of hydrogels and nanocomposites films in wound healing applications [ 21 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

Abdollahi

Zare‬

Salimi

et al. 2021

IJMS

108

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In this study, nanocomposite hydrogels composed of sodium carboxymethylated starch (CMS)-containing CuO nanoparticles (CMS@CuO) were synthesized and used as experimental wound healing materials. The hydrogels were fabricated by a solution-casting technique using citric acid as a crosslinking agent. They were characterized by Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and thermogravimetric analysis (TGA) to evaluate their physicochemical properties. In addition, swelling, antibacterial activities, antioxidant activities, cytotoxicity, and in vivo wound healing were investigated to evaluate the wound healing potential of the CMS@CuO nanocomposite hydrogels. Growth inhibition of the Gram-positive and Gram-negative pathogens, antioxidant activity, and swelling were observed in the CMS@CuO nanocomposite hydrogels containing 2 wt.% and 4 wt.% CuO nanoparticles. The hydrogel containing 2 wt.% CuO nanoparticles displayed low toxicity to human fibroblasts and exhibited good biocompatibility. Wounds created in rats and treated with the CMS@2%CuO nanocomposite hydrogel healed within 13 days, whereas wounds were still present when treated for the same time-period with CMS only. The impact of antibacterial and antioxidant activities on accelerating wound healing could be ascribed to the antibacterial and antioxidant activities of the nanocomposite hydrogel. Incorporation of CuO nanoparticles in the hydrogel improved its antibacterial properties, antioxidant activity, and degree of swelling. The present nanocomposite hydrogel has the potential to be used clinically as a novel wound healing material.

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In-vitro and in-vivo study of superabsorbent PVA/Starch/g-C3N4/Ag@TiO2 NPs hydrogel membranes for wound dressing

Cited by 87 publications

References 66 publications

Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool

Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

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