In vitro and in vivo genotoxicity of radiofrequency fields

Verschaeve, Luc; Juutilainen, Jukka; Lagroye, I.; Miyakoshi, Junji; Saunders, Richard D. E.; Seze, René de; Tenforde, T.S.; Rongen, Eric van; Veyret, B.; Xu, Zhengping

doi:10.1016/j.mrrev.2010.10.001

Cited by 100 publications

(59 citation statements)

References 157 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, two other recent meta-analyses concluded that long-term ipsilateral users of mobile phone have an increased risk of glioma (OR =1.46; 95% CI, 1.12-1.92) (7), whereas no significant association was found with meningioma [relative risk (RR), 0.98; 95% CI, 0.75-1.28] or acoustic neurinoma (RR =1.14; 95% CI, 0.65-1.99) in long-term mobile phone users (i.e., ≥10 years) (8). Indeed, experimental evidence was brought about potential genetic damage of RFs emitted by mobile phones in human cells (9). Consistent with different groups of researches, RFs were proven to induce DNA single-and double-strand breaks (DSB), the latter being thought to be the most severe form of DNA damage since they may lead to severe losses of large fragments of DNA.…”

Section: Introductionmentioning

confidence: 99%

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

View full text Add to dashboard Cite

Background: The use of mobile phones has been associated with an increased risk of developing certain type of cancer, especially in long term users. Therefore, this study was aimed to investigate the potential genotoxic effect of mobile phone radiofrequency exposure on human peripheral blood mononuclear cells in vitro. Methods:The study population consisted in 14 healthy volunteers. After collection of two whole blood samples, the former was placed in a plastic rack, 1 cm from the chassis of a commercial mobile phone (900 MHz carrier frequency), which was activated by a 30-min call. The second blood sample was instead maintained far from mobile phones or other RF sources. The influence of mobile phone RF on DNA integrity was assessed by analyzing γ-H2AX foci in lymphocytes using immunofluorescence staining kit on AKLIDES.Results: No measure of γ-H2AX foci was significantly influenced by mobile phone RF exposure, nor mobile phone exposure was associated with significant risk of genetic damages in vitro (odds ratio comprised between 0.27 and 1.00). Conclusions:The results of this experimental study demonstrate that exposure of human lymphocytes to a conventional 900 MHz RF emitted by a commercial mobile phone for 30 min does not significantly impact DNA integrity.

show abstract

Section: Introductionmentioning

confidence: 99%

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

View full text Add to dashboard Cite

show abstract

“…It is unlikely that low-level exposure to RF as seen in our study has enough energy to cause heating. 20 However, biological effects can also occur in which RF heating is neither an adequate nor a possible mechanism. 21 Animal studies and in vitro studies have shown genetic effects after RF exposure, but the results vary 20 and have not been confirmed in human studies.…”

Section: Discussionmentioning

confidence: 99%

“…20 However, biological effects can also occur in which RF heating is neither an adequate nor a possible mechanism. 21 Animal studies and in vitro studies have shown genetic effects after RF exposure, but the results vary 20 and have not been confirmed in human studies. It has been suggested 22 that there are several thermoreceptor molecules in cells, and that they also at lower temperatures than when the ordinary thermic effects are registered, activate a cascade of second and third messenger systems, gene expression mechanisms and production of heat shock proteins in order to defend the cell against metabolic cell stress caused by heat.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes After Paternal Radiofrequency Field Exposure Aboard Fast Patrol Boats

Baste¹,

Moen²,

Oftedal³

et al. 2012

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

“…ry committees in several countries and international organizations were similar: the currently available data did not provide sufficient evidence that RF exposure per se is genotoxic (reviewed in Verschaeve et al 2010;Verchaeve 2012). The issue related to RF emitted from mobile phone use and the development of brain cancer was examined in several epidemiological investigations.…”

mentioning

confidence: 99%

Mobile Phones, Non-Ionizing Radiofrequency Fields and Brain Cancer: Is There an Adaptive Response?

Vijayalaxmi

Prihoda²

2014

Dose-Response

View full text Add to dashboard Cite

ᮀ There is widespread concern among the general public regarding the ever increasing use of mobile phones. The concern is mainly because the antenna which transmits nonionizing radiofrequency fields is held close to the head during use and thus might cause brain cancer. By far, the largest epidemiological study was conducted by the INTER-PHONE study group and the results were published in 2011. The author's conclusions were (i) no increased risk of meningioma and glioma in mobile phone users and (ii) there were suggestions of an increased risk for glioma at the highest exposure levels but, bias and error prevented a causal interpretation. We have carefully examined all of the odd ratios presented in the INTERPHONE study publication: our results showed 24.3% decreased and 0.7% increased risk for meningioma and 22.1% decreased and 6.6% increased risk for glioma. Hence, we hypothesize that the overwhelming evidence for the decreased risk for both diseases may be due to the induction of 'adaptive response' which is well-documented in scientific literature

show abstract

In vitro and in vivo genotoxicity of radiofrequency fields

Cited by 100 publications

References 157 publications

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Pregnancy Outcomes After Paternal Radiofrequency Field Exposure Aboard Fast Patrol Boats

Mobile Phones, Non-Ionizing Radiofrequency Fields and Brain Cancer: Is There an Adaptive Response?

Contact Info

Product

Resources

About