In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

“…This could be explained either by high GSH utilization for conjugation and/or its participation in neutralizing free radicals generated by MMI exposure. Our results are in agreement with previous reports of Bagchi et al (1995) and Baskol et al (2007) who demonstrated that hypothyroidism might generate reactive oxygen species (ROS), which in turn could enhance lipid peroxidation leading to DNA damage. Co‐administration of Se to MMI‐treated rats restored MDA and GSH levels to near normal values in their pups.…”

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

“…This could be explained either by high GSH utilization for conjugation and/or its participation in neutralizing free radicals generated by MMI exposure. Our results are in agreement with previous reports of Bagchi et al (1995) and Baskol et al (2007) who demonstrated that hypothyroidism might generate reactive oxygen species (ROS), which in turn could enhance lipid peroxidation leading to DNA damage. Co‐administration of Se to MMI‐treated rats restored MDA and GSH levels to near normal values in their pups.…”

Cytogenetic damage in female Pakistani agricultural workers exposed to pesticides

“…The significant decrease in the level of SChE in workers indicates that exposure to pesticides during cotton picking has the potential to disrupt nervous system function. These results are consistent with the findings of previous studies [Bogden et al, 1975;Mishra et al, 1985;Bagchi et al, 1995;Bhalli et al, 2006a]. The exposed population in this study was exposed to a complex mixture of pesticides, so it was not possible to predict whether the overall effect was clastogenic or eneugenic without carrying out fluorescent in situ hybridization with centromeric probes.…”

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

“…In the current study, DM induced a significant increase in the levels of MDA accompanied by a significant decrease in GSH content in liver tissues. Our results are in agreement with similar data reported in different experimental models of rats exposed to dimethoate and other pesticides [11,13,37,40,[42][43][44]. In fact, DM is a lipophilic substance and therefore it can interact with cellular liver membrane.…”

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

“…This could be explained either by high GSH utilization for conjugation and/or its participation in neutralizing free radicals generated by MMI exposure. Our results are in agreement with previous reports of Bagchi et al (1995) and Baskol et al (2007) who demonstrated that hypothyroidism might generate reactive oxygen species (ROS), which in turn could enhance lipid peroxidation leading to DNA damage. Co‐administration of Se to MMI‐treated rats restored MDA and GSH levels to near normal values in their pups.…”

Cytogenetic damage in female Pakistani agricultural workers exposed to pesticides

“…The significant decrease in the level of SChE in workers indicates that exposure to pesticides during cotton picking has the potential to disrupt nervous system function. These results are consistent with the findings of previous studies [Bogden et al, 1975;Mishra et al, 1985;Bagchi et al, 1995;Bhalli et al, 2006a]. The exposed population in this study was exposed to a complex mixture of pesticides, so it was not possible to predict whether the overall effect was clastogenic or eneugenic without carrying out fluorescent in situ hybridization with centromeric probes.…”

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

“…In the current study, DM induced a significant increase in the levels of MDA accompanied by a significant decrease in GSH content in liver tissues. Our results are in agreement with similar data reported in different experimental models of rats exposed to dimethoate and other pesticides [11,13,37,40,[42][43][44]. In fact, DM is a lipophilic substance and therefore it can interact with cellular liver membrane.…”

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

“…This could be explained either by high GSH utilization for conjugation and/or its participation in neutralizing free radicals generated by MMI exposure. Our results are in agreement with previous reports of Bagchi et al (1995) and Baskol et al (2007) who demonstrated that hypothyroidism might generate reactive oxygen species (ROS), which in turn could enhance lipid peroxidation leading to DNA damage. Co‐administration of Se to MMI‐treated rats restored MDA and GSH levels to near normal values in their pups.…”

Cytogenetic damage in female Pakistani agricultural workers exposed to pesticides

“…The significant decrease in the level of SChE in workers indicates that exposure to pesticides during cotton picking has the potential to disrupt nervous system function. These results are consistent with the findings of previous studies [Bogden et al, 1975;Mishra et al, 1985;Bagchi et al, 1995;Bhalli et al, 2006a]. The exposed population in this study was exposed to a complex mixture of pesticides, so it was not possible to predict whether the overall effect was clastogenic or eneugenic without carrying out fluorescent in situ hybridization with centromeric probes.…”

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

“…In the current study, DM induced a significant increase in the levels of MDA accompanied by a significant decrease in GSH content in liver tissues. Our results are in agreement with similar data reported in different experimental models of rats exposed to dimethoate and other pesticides [11,13,37,40,[42][43][44]. In fact, DM is a lipophilic substance and therefore it can interact with cellular liver membrane.…”