volume 6, issue 5, Pe1626 2012
DOI: 10.1371/journal.pntd.0001626
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Abstract: BackgroundAntitumor cyclopalladated complexes with low toxicity to laboratory animals have shown leishmanicidal effect. These findings stimulated us to test the leishmanicidal property of one palladacycle compound called DPPE 1.2 on Leishmania (Leishmania) amazonensis, an agent of simple and diffuse forms of cutaneous leishmaniasis in the Amazon region, Brazil.Methodology/Principal FindingsPromastigotes of L. (L.) amazonensis and infected bone marrow-derived macrophages were treated with different concentratio…

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