In vitro activity of quinolones against isolates from paediatric urinary tract infections from three Venezuelan centres

Antimicrobial resistance of Pseudomonas aeruginosa in pediatric infections

“…3,4 Recent studies have reduced safety concerns over the use of quinolones in pediatric patients. Combined with the good antimicrobial activity shown in this and other studies, 5 this makes them a good empirical choice for community-acquired infections. Local surveillance of antimicrobial activity should be done periodically to guide antimicrobial therapy, especially as carbapenem-resistant P. aeruginosa has been reported as an emerging problem in Latin America.…”

“…4 In utero and perinatal exposure to NRTIs are known to cause hyperlactatemia (HLA) from mitochondrial toxicity. 5,6 An HIV-infected mother detected at 30 weeks of pregnancy was treated with lamivudine, stavudine, and nevirapine. A live male baby weighing 2135 g was delivered by elective cesarean section at 38 weeks of gestation with intrapartum intravenous zidovudine cover as per PACTG 076 protocol.…”