In Utero and Childhood Polybrominated Diphenyl Ether (Pbde) Exposures and Neurodevelopment in the Chamacos Study

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

“…Prof. Eskenazi and her team examine the relationships between serum PBDEs and children's neurobehavioral development, including attention, motor functioning, and cognition, to show the negative impact of PBDEs in maternal serum transmitted during the perinatal period on Verbal Comprehension IQ when the children reached 7 years old. They also find an inverse association of PBDEs in children's serum with children's Full-Scale IQ and Processing Speed IQ at the age of 7 (Eskenazi et al, 2013).…”

“…Cord blood FT4 was slightly correlated with increased BDE-99, but weakly correlated with decreased in the neurodevelopment of infants, toddlers, or young children (Roze et al, 2009;Herbstman et al, 2010;Gascon et al, 2011;Shy et al, 2011;Gascon et al, 2012;Hoffman et al, 2012;Eskenazi et al, 2013) in Table 3. Although it has been demonstrated that PBDEs exposure delays the neurodevelopment of neonates and adults in animal models, only four epidemiological studies have examined the correlations between infants' or toddlers' neurodevelopment and PBDEs exposure, particularly for octaBDEs, nonaBDEs, and decaBDE (Herbstman et al, 2010;Chao et al, 2011;Shy et al, 2011;Gascon et al, 2012).…”

“…Toddlers in this PIN cohort study were assessed using the Infant-Toddler Social and Emotional Assessment (ITSEA) test. A new CHAMACOS study has shown an association between prenatal and childhood PBDE exposure and neurodevelopmental problems when the children are 5 (n = 310) and 7 (n = 323) years old (Eskenazi et al, 2013). Prof. Eskenazi and her team examine the relationships between serum PBDEs and children's neurobehavioral development, including attention, motor functioning, and cognition, to show the negative impact of PBDEs in maternal serum transmitted during the perinatal period on Verbal Comprehension IQ when the children reached 7 years old.…”

PBDE flame retardants

“…The dominant PBDEs measured in biota (i.e., BDE-47, -99, -100, -153, and -154) are deposited to lipophilic tissue compartments, and these congeners continue to be detected in human serum, breast tissue, and milk 18,64,65 and in adipose tissues of a variety of wildlife, including free ranging fish species. 17,66,67 PBDEs have been shown to cross the blood-placenta and bloodbrain barriers to accumulate in the brains of perinatally exposed rats exposed to the PentaBDE commercial mixture 68 and some birds of prey.…”

“…207 Moreover, maternal prenatal and childhood PBDE exposures have been associated with reduced attention, fine motor coordination, and cognition (declines in IQ scores) among a California cohort of MexicanAmerican children. 64 A substantial number of studies in rodents, spanning different laboratories, have demonstrated also that PBDEs can elicit adverse neurobehavioral outcomes in early development. [208][209][210] Recent in vitro work has even shown that the prominent OH-BDE metabolite in humans, 6-OH-BDE-47, can disrupt adult neurogenesis by inhibiting neuronal differentiation and oligodendrocyte differentiation, proliferation, and survival of primary cultured adult neural stem/progenitor cells isolated from the brains of adult mice.…”