In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial

Montfoort, Aafke P.A. van; Fiddelers, Audrey A. A.; Janssen, J.Marij; Derhaag, Josien G.; Dirksen, Carmen D.; Dunselman, G.A.J.; Land, Jolande A.; Geraedts, J. P. M.; Evers, Johannes L.H.; Dumoulin, J.C.M.

doi:10.1093/humrep/dei359

Cited by 177 publications

(138 citation statements)

References 23 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Clearly, eSBT must be applied selectively to a good prognosis cohort. Randomized prospective trials have demonstrated that, in an unselected patient population, eSET can significantly compromise PR [30]. Our results suggest, however, that age alone should not automatically prevent inclusion in a good prognosis cohort.…”

Section: Discussionmentioning

confidence: 60%

Age-related success with elective single versus double blastocyst transfer

Friedman

Davis

Lathi

et al. 2008

Fertility and Sterility

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 60%

Age-related success with elective single versus double blastocyst transfer

Friedman

Davis

Lathi

et al. 2008

Fertility and Sterility

View full text Add to dashboard Cite

“…Finally, we applied observed age-specific probabilities of going on to subsequent frozen cycles following failed frozen cycles, and assumed that these probabilities would be the same following eSET and DET. 28,29 Age-specific discontinuation rates following completed treatment cycles (i.e. fresh cycles with associated frozen/thawed cycles) were also estimated from the clinical data set and the same rates were applied for eSET and DET.…”

Section: Linking Cyclesmentioning

confidence: 99%

Minimising twins in in vitro fertilisation: a modelling study assessing the costs, consequences and cost-utility of elective single versus double embryo transfer over a 20-year time horizon

Scotland

McLernon

Kurinczuk

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

View full text Add to dashboard Cite

Objectives To assess the cumulative costs and consequences of double embryo transfer (DET) or elective single embryo transfer (eSET) in women commencing in vitro fertilisation (IVF) treatment aged 32, 36 and 39 years. Design Microsimulation model.Setting Three assisted reproduction centres in Scotland.Sample A total of 6153 women undergoing treatment at one of three Scottish IVF clinics, between January 1997 and June 2007.Methods A microsimulation model, populated using data inputs derived from a large clinical data set and published literature, was developed to compare the costs and consequences of using eSET or DET over multiple treatment cycles.Main outcome measures Disability-free live births; twin pregnancy rate; women's quality-adjusted life-years (QALYs); health service costs.Results Not only did DET produce a higher cumulative live birth rate compared with eSET for women of all three ages, but also a higher twin pregnancy rate. Compared with eSET, DET ranged from costing an additional £27 356 per extra live birth in women commencing treatment aged 32 years, to costing £15 539 per extra live birth in 39-year-old women. DET cost £28 300 and £20 300 per additional QALY in women commencing treatment aged 32 and 39 years, respectively.Conclusions Considering the high twin pregnancy rate associated with DET, coupled with uncertainty surrounding QALY gains, eSET is likely to be the preferred option for most women aged £36 years. The cost-effectiveness of DET improves with age, and may be considered cost-effective in some groups of older women. The decision may best be considered on a case-by-case basis for women aged 37-39 years.Keywords Cost-effectiveness, in vitro fertilisation, single embryo transfer.Please cite this paper as: Scotland G, McLernon D, Kurinczuk J, McNamee P, Harrild K, Lyall H, Rajkhowa M, Hamilton M, Bhattacharya S. Minimising twins in in vitro fertilisation: a modelling study assessing the costs, consequences and cost-utility of elective single versus double embryo transfer over a 20-year time horizon.

show abstract

“…Six RCTs, comparing forms of SET with DET in, generally, patients with a good prognosis, 10,[12][13][14][15][16][17][18] and a Cochrane review 6 have been undertaken. SET alone gave poorer outcomes in terms of live birth rate per embryo transfer cycle but reduced the incidence of twins to a rate comparable with natural pregnancies.…”

Section: Elective Single Embryo Transfer Trialsmentioning

confidence: 99%

“…Most of the trials explicitly included only good prognosis patients, and beyond this it is to be expected that better prognosis patients would be more likely to consent to participate in a trial, as shown by comparisons between those who consented and those who refused in two of the trials. 14,18 It is also generally accepted that patients in clinical trials have better outcomes than is routine.…”

Section: Comparison With Data From Randomised Trialsmentioning

confidence: 99%

Towards single embryo transfer? Modelling clinical outcomes of potential treatment choices using multiple data sources: predictive models and patient perspectives

Roberts

McGowan²,

Hirst³

et al. 2010

Health Technol Assess

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of project...

show abstract

In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial

Cited by 177 publications

References 23 publications

Age-related success with elective single versus double blastocyst transfer

Age-related success with elective single versus double blastocyst transfer

Minimising twins in in vitro fertilisation: a modelling study assessing the costs, consequences and cost-utility of elective single versus double embryo transfer over a 20-year time horizon

Towards single embryo transfer? Modelling clinical outcomes of potential treatment choices using multiple data sources: predictive models and patient perspectives

Contact Info

Product

Resources

About