In situ-transition nanozyme triggered by tumor microenvironment boosts synergistic cancer radio-/chemotherapy through disrupting redox homeostasis

Yuan, Zhongwen; Liu, Xinxin; Ling, Jiabao; Huang, Guanning; Huang, Jia‐Run; Zhu, Xueqiong; He, Lizhen; Chen, Tianfeng

doi:10.1016/j.biomaterials.2022.121620

Cited by 43 publications

(30 citation statements)

References 50 publications

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“…Therefore, Yuan et al constructed a TME-responsive nanozyme with a reversible Mn 3+ /Mn 2+ transition triggered by the TME to perturb the intrinsic redox homeostasis and catalyze the overproduction of ROS. 309 The nanozyme exhibited mainly POD-like activity, catalyzing the formation of ˙OH from O 2 , and thereby enhancing the oxidative environment of TME. In combination with RT, high-energy X-rays could excite the outer electrons in the nanozyme to form photoelectrons, which participated in the POD-like enzymatic reaction, thereby enhancing ROS accumulation and amplifying the therapeutic effect.…”

Section: Ros Upregulation-potentiated/synergized Cancer Therapymentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

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Section: Ros Upregulation-potentiated/synergized Cancer Therapymentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

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“…Recently, Yuan and coworkers constructed a TME-responsive nanozyme, DOX@HMSN/Mn 3 O 4 (R) [ 64 ]. This nanozyme shows activities similar to OXD and CAT, alleviating hypoxic conditions in the TME and reversing the Mn 3+ /Mn 2+ transformation by TME via in situ triggering, thus disrupting the excessive production of intrinsic redox steady-state catalysis (ROS).…”

Section: Classification Of Nanozymesmentioning

confidence: 99%

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

et al. 2023

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New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes.

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“…On the one hand, nanozymes have the advantage of their enzyme-mimic activities to catalase abundant ROS generation, which cause redox homeostasis disruption and damage to the cell membrane (Yuan et al, 2022). The direct effect of nanozymes can alleviate drug resistance and even kill cancer cells.…”

Section: Nanozymes In Chemotherapymentioning

confidence: 99%

Progress and prospects of nanozymes for enhanced antitumor therapy

Zhao

Yuan

et al. 2022

Front. Chem.

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Nanozymes are nanomaterials with mimicked enzymatic activity, whose catalytic activity can be designed by changing their physical parameters and chemical composition. With the development of biomedical and material science, artificially created nanozymes have high biocompatibility and can catalyze specific biochemical reactions under biological conditions, thus playing a vital role in regulating physiological activities. Under pathological conditions, natural enzymes are limited in their catalytic capacity by the varying reaction conditions. In contrast, compared to natural enzymes, nanozymes have advantages such as high stability, simplicity of modification, targeting ability, and versatility. As a result, the novel role of nanozymes in medicine, especially in tumor therapy, is gaining increasing attention. In this review, function and application of various nanozymes in the treatment of cancer are summarized. Future exploration paths of nanozymes in cancer therapies based on new insights arising from recent research are outlined.

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In situ-transition nanozyme triggered by tumor microenvironment boosts synergistic cancer radio-/chemotherapy through disrupting redox homeostasis

Cited by 43 publications

References 50 publications

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

Progress and prospects of nanozymes for enhanced antitumor therapy

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