2006
DOI: 10.1021/cg0503402
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Abstract: In this paper, we present the application of four different in situ analytical techniques to monitor the solvent-mediated polymorphic transformation of L-glutamic acid. Focused beam reflectance measurement (FBRM) and particle vision and measurement (PVM) have been used to track the chord length and morphology of the crystals over the course of the transformation. The polymorphic forms present have been monitored using Raman spectroscopy, while attenuated total reflection Fourier transform infrared (ATR-FTIR) s… Show more

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Cited by 242 publications
(354 citation statements)
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“…180 L-Glutamic acid has multiple polymorphs and the needle-like β form has been the subject of several in situ imaging studies modeled by multi-dimensional population balances to estimate growth kinetics. 192,199,200 Kempkes et al 193 presented a procedure to interpret in situ images to estimate growth rates of a population of cuboids. The experimental studies presented here are generally limited to measuring growth rates in two directions due to the 2D imaging techniques currently available; however, in the future with proper 3D imaging, growth rates of individual facets could be measured.…”
Section: Particle Size and Shape Characterizationmentioning
confidence: 99%
“…180 L-Glutamic acid has multiple polymorphs and the needle-like β form has been the subject of several in situ imaging studies modeled by multi-dimensional population balances to estimate growth kinetics. 192,199,200 Kempkes et al 193 presented a procedure to interpret in situ images to estimate growth rates of a population of cuboids. The experimental studies presented here are generally limited to measuring growth rates in two directions due to the 2D imaging techniques currently available; however, in the future with proper 3D imaging, growth rates of individual facets could be measured.…”
Section: Particle Size and Shape Characterizationmentioning
confidence: 99%
“…Therefore, the dissolution rate was the controlling factor for Form II seeded transformation crystallization. The measured solute concentration and known solubility of Form II were used to estimate the dissolution rate according to following Sherwood based equation [7]:…”
Section: ) Dissolution Rate Of Form IImentioning
confidence: 99%
“…Although the kinetic estimation can be a nontrivial task, accurate kinetic information is very important for obtaining a reliable process model for polymorphic crystallization. Such model can accelerate process design, finding optimal operating conditions as well as development of suitable control strategy [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…Sophisticated methods are used for in situ analysis during crystallization. For example, Schöll et al (15) used a combination of different fiber-optic measurement techniques to determine solution concentration, the morphology of the solid particles, and the solid state of the compound being crystallized. With similar approaches, many times more information could be extracted from a dissolution test as well.…”
Section: How To Extract Solid-state Information From the Dissolution mentioning
confidence: 99%