In situ formation of multiple stimuli-responsive poly[(methyl vinyl ether)-alt-(maleic acid)]-based supramolecular hydrogels by inclusion complexation between cyclodextrin and azobenzene

Ma, Xiaoe; Zhou, Naizhen; Zhang, Tianzhu; Guo, Zhenchao; Hu, Wusheng; Zhu, Changhao; Ma, Dandan; Gu, Ning

doi:10.1039/c5ra22541h

Cited by 27 publications

(18 citation statements)

References 54 publications

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“…CD/azobenzene‐grafted polymers such as dextran, curdlan, polyacrylamide, hyaluronan, and poly(methyl vinyl ether‐ alt ‐maleic acid) have been used to prepare CD‐based light‐responsive supramolecular gels . As an example, Harada et al prepared α‐CD‐functionalized curdlan and azobenzene‐modified poly(acrylic acid) to form supramolecular hydrogels, which changed to the sol with a decrease in viscosity under UV light irradiation, as shown in Figure .…”

Section: Cd‐based Light‐responsive Supramolecular Systemsmentioning

confidence: 99%

Recent Advances in Cyclodextrin‐Based Light‐Responsive Supramolecular Systems

Zhang

Wang

et al. 2018

Macromol. Rapid Commun.

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Cyclodextrins (CDs), one of the host molecules in supramolecular chemistry, can host guest molecules to form inclusion complexes via non-covalent and reversible host-guest interactions. CD-based light-responsive supramolecular systems are typically constructed using CDs and guest molecules with light-responsive moieties, including azobenzene, arylazopyrazole, o-nitrobenzyl ester, pyrenylmethyl ester, coumarin, and anthracene. To date, numerous efforts have been reported on the topic of CD-based light-responsive supramolecular systems, but these have not yet been highlighted in a separated review. This review summarizes the efforts reported over the past ten years. The main text of this review is divided into five sections (vesicles, micelles, gels, capturers, and nanovalves) according to the formation of self-assemblies. This feature article aims to afford a comprehensive understanding of the light-responsive moieties used in the construction of CD-based light-responsive supramolecular systems and to provide a helpful guide for the further design of CD-based light-responsive supramolecular systems.

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Section: Cd‐based Light‐responsive Supramolecular Systemsmentioning

confidence: 99%

Recent Advances in Cyclodextrin‐Based Light‐Responsive Supramolecular Systems

Zhang

Wang

et al. 2018

Macromol. Rapid Commun.

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“…149 In They suggested these multiple stimuli-responsive P(MVE-alt-MA)-based supramolecular hydrogels as a three-dimensional (3D) cell culture matrix or as a vehicle for the delivery of drugs and therapeutic cells. 150 Polymers can be used in combination with other nanoparticles (such as gold, silica, iron oxide, quantum dots etc.) to create multicomponent/layer gene delivery systems to provide multiple responsiveness.…”

Section: Dual and Multi Responsive Designsmentioning

confidence: 99%

Stimuli responsive polymer-based strategies for polynucleotide delivery

Altınkaya

Mallapragada

2017

J. Mater. Res.

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“…[ 15–18 ] Disulfide‐based polymers can react with high glutathione in the tumor microenvironment to form sulfhydryl groups. [ 19,20 ] Polymers based on hydrazone bonds, [ 21 ] hemiacetals, [ 22 ] vinyl ethers, [ 23 ] and other structures can break upon acid stimulation, resulting in rapid drug release. Moreover, light has been considered as a flexible, precise, and non‐invasive element for “smart” therapy.…”

Section: Introductionmentioning

confidence: 99%

Light‐Controlled Nanosystem with Size‐Flexibility Improves Targeted Retention for Tumor Suppression

Luo

Kong

Zhang

et al. 2021

Adv Funct Materials

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Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time in the tumor. Herein, a nanosystem that can modulate the particle size in situ by near‐infrared (NIR) light is self‐assembled by cross‐linking the surface‐modified poly(lactic‐co‐glycolic acid) from the up‐conversion nanoparticle with indocyanine green and doxorubicin–nitrobenezene–polyethylene glycol (DOX–NB–PEG). The nanosystem with its small size (≈100 nm) achieves better tumor targeting, while the PEG on the surface of the nanosystem can effectively shield the adsorption of proteins during blood circulation, maintaining a stable nanostructure and achieving good tumor targeting. Moreover, the nanosystem at the tumor realizes the rapid shedding of PEG on its surface by NIR irradiation, and the enhanced cellular uptake. At the same time, aggregation occurs inside the nanosystem to form bigger particles (≈600 nm) in situ, prolonging the retention time at the tumor and producing enhanced targeted therapeutic effects. In vitro data show higher cellular uptake and a higher rate of apoptosis after irradiation, and the in vivo data prove that the nanosystem have a longer residence time at the tumor site after NIR irradiation. This nanosystem demonstrates an effective therapeutic strategy in targeted synergistic tumors.

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In situ formation of multiple stimuli-responsive poly[(methyl vinyl ether)-alt-(maleic acid)]-based supramolecular hydrogels by inclusion complexation between cyclodextrin and azobenzene

Abstract: Stimuli-responsive poly[(methyl vinyl ether)-alt-(maleic acid)]-based supramolecular hydrogels were prepared in situ by inclusion complexation between cyclodextrin and azobenzene. They may have high potential in biomedical applications.

Cited by 27 publications

References 54 publications

Recent Advances in Cyclodextrin‐Based Light‐Responsive Supramolecular Systems

Recent Advances in Cyclodextrin‐Based Light‐Responsive Supramolecular Systems

Stimuli responsive polymer-based strategies for polynucleotide delivery

Light‐Controlled Nanosystem with Size‐Flexibility Improves Targeted Retention for Tumor Suppression

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