In situ fabrication of hollow hydroxyapatite microspheres by phosphate solution immersion

Wang, Yingchun; Yao, Aihua; Huang, Wenhai; Wang, Deping; Zhou, Jun

doi:10.1016/j.jcrysgro.2011.05.024

Cited by 20 publications

(5 citation statements)

References 40 publications

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“…In addition, the samples exhibit the ν 3 vibrational mode of carbonate ion at 1456 and 1419 cm −1 , as well as the ν 2 vibrational mode of carbonate ion at 874 cm −1 , which is assigned to the (CO 3 ) 2− group of B-type HAP [ 28 , 29 ]. The absorption band at 1566 cm −1 is associated with the (CO 3 ) 2− substituted for OH − as A-type substitution [ 30 ]. The presence of (CO 3 ) 2− group in the HAP lattice may be derived from the dissolved CO 2 from atmosphere.…”

Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Hydrothermal Rapid Synthesis of Calcium Phosphates: Structural Control and Application in Protein Adsorption

Cai

Fan

et al. 2015

Nanomaterials

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Synthetic calcium phosphate (CaP)-based materials have attracted much attention in the biomedical field. In this study, we have investigated the effect of pH values on CaP nanostructures prepared using a microwave-assisted hydrothermal method. The hierarchical nanosheet-assembled hydroxyapatite (HAP) nanostructure was prepared under weak acidic conditions (pH 5), while the HAP nanorod was prepared under neutral (pH 7) and weak alkali (pH 9) condition. However, when the pH value increases to 11, a mixed product of HAP nanorod and tri-calcium phosphate nanoparticle was obtained. The results indicated that the pH value of the initial reaction solution played an important role in the phase and structure of the CaP. Furthermore, the protein adsorption and release performance of the as-prepared CaP nanostructures were investigated by using hemoglobin (Hb) as a model protein. The sample that was prepared at pH = 11 and consisted of mixed morphologies of nanorods and nanoprisms showed a higher Hb protein adsorption capacity than the sample prepared at pH 5, which could be explained by its smaller size and dispersed structure. The results revealed the relatively high protein adsorption capacity of the as-prepared CaP nanostructures, which show promise for applications in various biomedical fields such as drug delivery and protein adsorption.

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Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Hydrothermal Rapid Synthesis of Calcium Phosphates: Structural Control and Application in Protein Adsorption

Cai

Fan

et al. 2015

Nanomaterials

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“…ICP-MS has been regularly used for quantification of Ca and P in calcium phosphate samples [86][87][88] and is key to providing values of Ca/P mole ratios of calcium phosphate phases present. In the present study, sintered cow bone and biomorphic fibres (as formed and final product) were dissolved in nitric acid solution, diluted, filtered and analysed by ICP-MS.…”

Section: Inductively Coupled Plasma-mass Spectrometry (Icp-ms)mentioning

confidence: 99%

Study of biomorphic calcium deficient hydroxyapatite fibres derived from a natural Harakeke (Phormium tenax) leaf fibre template

Siddiqui¹,

Pickering²,

Mucalo³

2020

Bioinspir. Biomim.

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The complex structure of natural bio-organic matter has inspired scientists to utilise these as templates to design "biomorphic materials", which retain the intricate architecture of the materials while acting as a useful bioactive material. Biomorphic hydroxyapatite-based fibres were synthesised using Harakeke leaf fibre as a template, which constitutes a powerful method for manufacturing bioactive ceramic fibres. Furthermore, in creating the hydroxyapatite-based fibres, a natural source of calcium and phosphate ions (from bovine bone) was utilised to create the digest solution in which the leaf fibres were immersed prior to their calcination to form the inorganic fibres. Chemical, thermogravimetric and microscopic characterisation confirmed that the final product was able to successfully replicate the shape of the fibres and furthermore be transformed into calcium deficient, bone-like hydroxyapatite.

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“…Amongst them, nanoparticle-assembled hollow microspheres provide advantages to adsorbents because they have higher specific areas for adsorption in comparison with simple microspheres and are more convenient to handle in comparison with nanoparticles [5, 7, 8]. Hollow HA microspheres can be synthesized using various methods including spray drying [9], solvothermal/hydrothermal synthesis [6, 10, 11], conversion CaCO 3 microspheres [12, 13, 14] and Li 2 O-CaO-B 2 O 3 [15,16], and assembly approaches with organic/inorganic materials. In assembly approaches, surfactants [17, 18], amino acids [19], polymers [20, 21, 22], and yeast cells [23] have been used to form hollow microspherical structures.…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption characteristics of nanoparticle-assembled hollow microspheres of hydroxyapatite and their composites with PLLA microporous membranes

Tanaka

Takai

Nagase

et al. 2019

Heliyon

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Nanoparticle-assembled hydroxyapatite (HA) hollow microspheres have a high surface area and are convenient to handle, owing to their characteristic structure. In this study we characterized the protein adsorption of HA hollow microspheres prepared from CaCl 2 and K 2 HPO 4 by a water-in-oil-in-water (W/O/W) emulsion method assisted by two surfactants: Span 80 and Tween 20. The HA hollow microspheres adsorbed bovine serum albumin, bovine γ-globulin, equine skeletal muscle myoglobin, and chicken egg white lysozyme in 10 mM sodium phosphate buffer (pH 6.8) in a Langmuir-type adsorption and desorbed the proteins in 800 mM sodium phosphate buffer (pH 6.8). The maximum adsorbed amounts of the HA hollow microspheres were 7.5–9.0 times higher than those of the microrods with a similar size range. The composite membranes of the HA microspheres and the poly( l -lactic acid) (PLLA) microporous membranes exhibited a high adsorption capacity for γ-globulin.

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In situ fabrication of hollow hydroxyapatite microspheres by phosphate solution immersion

Cited by 20 publications

References 40 publications

Microwave-Assisted Hydrothermal Rapid Synthesis of Calcium Phosphates: Structural Control and Application in Protein Adsorption

Microwave-Assisted Hydrothermal Rapid Synthesis of Calcium Phosphates: Structural Control and Application in Protein Adsorption

Study of biomorphic calcium deficient hydroxyapatite fibres derived from a natural Harakeke (Phormium tenax) leaf fibre template

Protein adsorption characteristics of nanoparticle-assembled hollow microspheres of hydroxyapatite and their composites with PLLA microporous membranes

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