2020
DOI: 10.1016/j.joim.2020.02.005
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Abstract: a b s t r a c tObjective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia. Methods: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory… Show more

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Cited by 402 publications
(394 citation statements)
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References 30 publications
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“…The previous study reported that dihydrotanshinone I also had inhibitory effects against viral entry and replication in the MERS-CoV through the cell model (14). In addition, the recent study showed dihydrotanshinone I could inhibit viral entry through binding to the fusion cone of spike protein which is important for viral membrane fusion (15).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The previous study reported that dihydrotanshinone I also had inhibitory effects against viral entry and replication in the MERS-CoV through the cell model (14). In addition, the recent study showed dihydrotanshinone I could inhibit viral entry through binding to the fusion cone of spike protein which is important for viral membrane fusion (15).…”
Section: Discussionmentioning
confidence: 99%
“…is -5.16 kcal/mol (15). In our previous study, we discovered that theaflavin (ZINC3978446) is a potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase (9).…”
Section: The Docking Binding Energy Between Dihydrotanshinone I and Smentioning
confidence: 99%
“…Emodin is a natural anthraquinone compound that is derived from the commonly used Chinese medicinal herbs, such as the genus Rheum and Polygonum [138]. Emodin was found to block the binding of SARS-CoV S protein with the enzyme ACE2 [139], while promazine is an old anti-psychotic drug with structural similarity to emodin. Promazine has shown inhibitory signs for the replication of SARS-CoV.…”
Section: Angiotensin Receptor Blocking Therapiesmentioning
confidence: 99%
“…Prescriptions are mainly used to improve immunity, balance human Qi, blood, Yin and Yang, and recover organ function. According to the study of COVID-19 treatment herbs [41,42], Chinese herbal medicines with a higher probability to directly inhibit SARS-CoV-2 have been selected, including Lianqiao, Gancao, Sangbaipi, Jinyinhua, Sangye, Pipaye, and other herbs, commonly used to treat viral pneumonia. Drugs should be selected and utilized according to the corresponding syndrome types.…”
Section: Prospectmentioning
confidence: 99%