In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer’s disease

Waqar, Maleeha; Batool, Sidra

doi:10.1016/j.jtbi.2015.02.028

Cited by 17 publications

(11 citation statements)

References 44 publications

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“…Six amino acid residues (Lys25, Arg24, Asn47, Pro31, Leu35 and Ala12) of fasciculin interact with the AChE residues by forming hydrogen bonds at its active site. Hydrophobic interactions are also observed between eight amino acid residues (Lys32, Cys59, Val34, Leu48, Ser26, Gly36, Thr15, Asn20) from fasciculin and the enzyme active site (Waqar and Batool, 2015). These interactions involve charged residues but lacks intermolecular salt linkages.…”

Section: Three-finger Toxins (3ftxs)mentioning

confidence: 99%

Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

et al. 2019

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Animal venoms have evolved over millions of years for prey capture and defense from predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides and proteins that induce harmful inflammatory and neurotoxic effects including severe pain and paralysis, hemotoxic effects, such as hemorrhage and coagulopathy, and cytotoxic/myotoxic effects, such as inflammation and necrosis. If untreated, many envenomings result in death or severe morbidity in humans and, despite advances in management, snakebite remains a major public health problem, particularly in developing countries. Consequently, the World Health Organization recently recognized snakebite as a neglected tropical disease that affects ∼2.7 million p.a. The major protein classes found in snake venoms are phospholipases, metalloproteases, serine proteases, and three-finger peptides. The mechanisms of action and pharmacological properties of many snake venom toxins have been elucidated, revealing a complex multifunctional cocktail that can act synergistically to rapidly immobilize prey and deter predators. However, despite these advances many snake toxins remain to be structurally and pharmacologically characterized. In this review, the multifunctional features of the peptides and proteins found in snake venoms, as well as their evolutionary histories, are discussed with the view to identifying novel modes of action and improving snakebite treatments.

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Section: Three-finger Toxins (3ftxs)mentioning

confidence: 99%

Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

et al. 2019

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“…Some efforts have been made in order to determine fasciculin-AChE complex structure and help the design of novel molecules with AChE inhibitory activity. Recent results from bioinformatics modeling revealed similar toxins with AChE potential inhibitory activity, supporting green mamba fasciculins as candidates for the development of AChE inhibitors to be used in AD ( Harel et al, 1995 ; Waqar and Batool, 2015 ).…”

Section: Animal Toxins To Treat Neurodegenerative Diseasesmentioning

confidence: 87%

Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases

et al. 2018

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Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairment, neuroinflammation, aging, aggregate formation, glutamatergic excitotoxicity, and apoptosis. Therefore, many research groups aim to identify drugs that may inhibit one or more of these events leading to neuronal cell death. Venoms are fruitful natural sources of new molecules, which have been relentlessly enhanced by evolution through natural selection. Several studies indicate that venom components can exhibit selectivity and affinity for a wide variety of targets in mammalian systems. For instance, an expressive number of natural peptides identified in venoms from animals, such as snakes, scorpions, bees, and spiders, were shown to lessen inflammation, regulate glutamate release, modify neurotransmitter levels, block ion channel activation, decrease the number of protein aggregates, and increase the levels of neuroprotective factors. Thus, these venom components hold potential as therapeutic tools to slow or even halt neurodegeneration. However, there are many technological issues to overcome, as venom peptides are hard to obtain and characterize and the amount obtained from natural sources is insufficient to perform all the necessary experiments and tests. Fortunately, technological improvements regarding heterologous protein expression, as well as peptide chemical synthesis will help to provide enough quantities and allow chemical and pharmacological enhancements of these natural occurring compounds. Thus, the main focus of this review is to highlight the most promising studies evaluating animal toxins as therapeutic tools to treat a wide variety of neurodegenerative conditions, including Alzheimer’s disease, Parkinson’s disease, brain ischemia, glaucoma, amyotrophic lateral sclerosis, and multiple sclerosis.

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“…Sin embargo, hay que tomar en cuenta que estos animales producen señales aposemáticas, que dan un mensaje de peligrosidad y ahuyentan a sus depredadores (MARTINEZ y MANJARREZ, 2017). De la misma manera, las personas mencionaron que reconocen una serpiente venenosa cuando sus colmillos son visibles, esta relación es correcta debido que las serpientes con dentición: proteroglifa poseen colmillos en su parte anterior, son fijos y los cubre una membrana conectada a una glándula venenosa (ZAVALA et al, 2002).…”

Section: Conocimiento Sobre Serpientesunclassified

Percepción Y Conocimientos De Serpientes en Una Zona Rural Y Urbana Del Ecuador

Haro

Proaño-Morales²

2019

ethnoscientia

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Desde el inicio de las civilizaciones, las personas han relacionado a diversas especies con deidades y les han atribuido propiedades especiales. Si bien en algunos casos este tipo de conocimiento se ha perdido, existen poblaciones que lo han mantenido a través del tiempo. Es de gran importancia preservar y divulgar esta información ya que forma parte de la sabiduría ancestral que favorece la conservación del patrimonio natural, cultural y ambiental. Para contribuir a este fin, la presente investigación tiene como objetivo principal documentar la percepción, el conocimiento y las diversas creencias que poseen las personas sobre serpientes en dos localidades del Ecuador, además de enseñar pautas de reconocimiento de especies venenosas y no venenosas. Para esto, se realizó un total de 97 entrevistas de tipo semiestructurada en una zona rural (Plaza de la parroquia 6 de julio, Cuellaje) y en otra urbana (Plaza Grande, Quito). Se obtuvieron como resultados una clara diferencia entre la zona rural y urbana; la mayoría de entrevistados/as sienten miedo al ver serpientes y evitan tener encuentros con las mismas; además, muchos desconocen cómo reconocer una serpiente venenosa y la función ecológica que estas cumplen en la naturaleza. Esta notable falta de conocimiento impide la conservación de este importante grupo, por lo que es necesario educar a las personas para evitar que estos reptiles se encuentren en categorías de amenaza.

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In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer’s disease

Cited by 17 publications

References 44 publications

Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases

Percepción Y Conocimientos De Serpientes en Una Zona Rural Y Urbana Del Ecuador

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