In rheumatoid arthritis, a polymorphism in the HLA-G gene concurs in the clinical response to methotrexate treatment

Baricordi, Olavio R.; Govoni, Marcello; Rizzo, Roberta; Trotta, Francesco

doi:10.1136/ard.2006.064022

Cited by 12 publications

(6 citation statements)

References 10 publications

(4 reference statements)

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“…Rizzo et al reported that HLA‐G −14 bp/−14 bp genotype could regulate the methotrexate‐treated response in RA patients with higher levels of HLA‐G and a consequent positive therapeutic result. In that study, a significantly higher frequency of the −14 bp/−14 bp genotype was observed in ‘responder’ patients compared with ‘nonresponders’ for clinical response to the methotrexate treatment (18, 34). Our recent study indicated that −14 bp/−14 bp polymorphism in the HLA‐G gene could be a risk factor for the pathogenesis of the idiopathic dilated cardiomyopathy (19).…”

Section: Discussionmentioning

confidence: 84%

Analysis of the 14 bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations

Yan

Lin

Li³

et al. 2008

Tissue Antigens

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The biological significance of human leukocyte antigen-G (HLA-G) is now beyond its initial concepts on the fetal-maternal immune regulation. HLA-G in various pathophysical conditions has been investigated, such as autoimmunity, tumor, inflammation and transplantation. HLA-G has also been postulated as a chemotherapy response marker both in protein and in genetic contexts. In the current study, a total of 640 Chinese Han and 258 Chinese She ethnic minority populations had been genotyped for the 14 bp insertion (114 bp) and deletion (214 bp) polymorphism in the HLA-G gene. Significant difference was observed for both the 114 bp/114 bp (15.2% in the Han and 6.6% in the She; P ¼ 0.00048, P c ¼ 0.00097) and 214 bp/214 bp (34.5% in the Han and 50.4% in the She; P ¼ 1.05 Â 10 25 , P c ¼ 2.1 Â 10 25 ) genotypes between the two populations, and similar significance was found for both 114 bp (40.3% in the Han and 28.1% in the She) and 214 bp allele distributions (P ¼ 1.2 Â 10 26 , P c ¼ 2.4 Â 10 26 ). Furthermore, frequencies of the 14 bp genotype and alleles both in the Chinese Han and in the Chinese She populations were compared with other ethnic populations. Data showed that dramatic variations between different ethnic populations were also observed for this polymorphism. In summary, our results indicate that heterogeneity of the 14 bp polymorphism in the HLA-G gene among different ethnic populations is possibly the result of evolution.Recently, a 14 bp insertion/deletion polymorphism (rs16375) in exon 8 in the 3#-untranslated region (3#UTR) of the HLA-G gene has gained its interest. Studies indicated that the 14 bp insertion/deletion polymorphism was associated with HLA-G mRNA stability and isoform alternative splicing pattern and then influenced HLA-G mRNA expression or detection of soluble HLA-G (5-7). Functions of HLA-G in fetalmaternal immune maintenance had been well documented, suggesting that HLA-G serves as a protection factor for fetus from maternal allorecognition by modulating both the functions of immune component cells such as natural killer (NK) cells, T lymphocytes, antigen-presenting cells and the cytokine balance during pregnancy (8-11).

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Section: Discussionmentioning

confidence: 84%

Analysis of the 14 bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations

Yan

Lin

Li³

et al. 2008

Tissue Antigens

View full text Add to dashboard Cite

show abstract

“…Of note, a 14-bp insertion/deletion polymorphism in the 3=-untranslated region of exon 8 of the HLA-G gene was reported to be associated with the stability and splicing pattern of HLA-G mRNA isoforms, consequently affects HLA-G protein expression patterns and has possible implications for clinical significance [14,15]. In line with this, Rizzo et al reported that HLA-G the 14-bp deletion homozygous genotype could regulate the methotrexate-treated response in rheumatoid arthritis patients with higher levels of HLA-G and a consequent positive therapeutic result [23]. However, this observation was challenged by the findings in another study that the HLA-G 14 bp polymorphism was not associated with the response to long-term therapy with methotrexate response in rheumatoid arthritis [24].…”

Section: Discussionmentioning

confidence: 88%

Analysis of the plasma soluble human leukocyte antigen–G and interleukin-10 levels in childhood atopic asthma

Zheng

et al. 2010

Human Immunology

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“…However, Kim et al lacked to find an association between HLA‐G −1202T>C and −586C>T polymorphisms and susceptibility to develop RA, while Veit et al associated the HLA‐G 14 bp del/ins polymorphism with juvenile idiopathic arthritis, but not with RA. Also the role of HLA‐G 14 bp del/ins polymorphism in relation to the treatment with methotrexate in RA patients seems controversial . Nevertheless it should be considered that most genetic association studies suffer from being based on small numbers of patients and controls.…”

Section: Clinical and Laboratorial Characteristic Of Rheumatoid Arthrmentioning

confidence: 99%

HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients

et al. 2014

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We analyzed the possible association between human leukocyte antigen-G (HLA-G) genetic variants, supposed to regulate HLA-G expression, and the susceptibility to develop rheumatoid arthritis (RA) as well as its clinical manifestations. The 5'upstream regulatory region (5'URR) and 3'untranslated region (3'UTR) regions of the HLA-G gene were screened in 127 RA patients and 128 controls: 10 5'URR and 3 3'UTR HLA-G polymorphisms as well as two haplotypes were associated with risk for RA development, while a polymorphism in the 5'URR showed an association with the degree of disease activity. These findings, although the number of cases analyzed is limited and the P-values are modest, indicate a possible association between HLA-G gene polymorphisms and susceptibility to develop RA disease and its severity.

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In rheumatoid arthritis, a polymorphism in the HLA-G gene concurs in the clinical response to methotrexate treatment

Cited by 12 publications

References 10 publications

Analysis of the 14 bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations

Analysis of the 14 bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations

Analysis of the plasma soluble human leukocyte antigen–G and interleukin-10 levels in childhood atopic asthma

HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients

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