In Mice, Tuberculosis Progression Is Associated with Intensive Inflammatory Response and the Accumulation of Gr-1dim Cells in the Lungs

Lyadova, Irina V.; Tsiganov, Evgeny N.; Kapina, Marina A.; Shepelkova, Galina; Sosunov, Vasily V.; Radaeva, Tatiana V.; Majorov, Konstantin; Shmitova, Natalya S.; Ham, Henk-Jan van den; Ganusov, Vitaly V.; Boer, Rob J. de; Racine, Rachael; Winslow, Gary M.

doi:10.1371/journal.pone.0010469

Cited by 70 publications

(84 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our observations made in F2 model support the involvement of T cells in TB exacerbation (Lyadova et al, 2010). In this model, susceptible mice displayed first signs of TB progression (i.e., wasting) on day 16 post-challenge and died on days 26-35 post-challenge.…”

Section: T Lymphocytes In Tb Exacerbationsupporting

confidence: 83%

“…In different models, susceptible mice produced more proinflammatory cytokines and developed stronger neutrophilic inflammation than resistant mice (Cardona et al, 2003;Eruslanov et al, 2004;Eruslanov et al, 2005;Keller et al, 2006). To directly address an association between inflammatory reactions and TB progression, we have recently analyzed TB severity and immune reactivity in a panel of genetically heterogeneous (A/SnxI/St)F2 hybrid mice (Lyadova et al, 2010). The hybrids originated from TB-highly-susceptible I/St and more resistant A/Sn mice that following challenge with Mtb displayed different rates of TB progression (Lyadova et al, 2000;Sanchez et al, 2003;Eruslanov et al, 2004).…”

Section: Mtb Infection In Hosts With Genetic Differences In the Extenmentioning

confidence: 99%

“…Thus, similarly to gene-targeted mice, in F2 mice severe infection was characterized by: (i) overexpression of proinflammatory factors and (ii) excessive infiltration of the lung tissue with neutrophil-like cells. Further analysis suggested that these manifestations were a consequence of increased transcription of proinflammatory factors in host macrophages and were predetermined genetically (Lyadova et al, 2010).…”

Section: Mtb Infection In Hosts With Genetic Differences In the Extenmentioning

confidence: 99%

“…The list includes proinflammatory cytokines IL-1 and TNF-, the major neutrophil attracting chemokines IL-8 and CXCL2, growth factors GM-CSF and VEGF, several metalloproteinases, IL-1Ra, TGF- (McColl et al, 1992;Cassatella, 1995;Riedel & Kaufamm, 1997;Petrofsky et al, 1999;Scapini et al, 2000;Matzer et al, 2001;Sawant & McMurray, 2007;Lyadova et al, 2010). The secretion is not high, but when neutrophils accumulate in high numbers, it may represent an important source of inflammatory factors.…”

Section: Functional Activitiesmentioning

confidence: 99%

“…To address a role for granulocytes in TB progression, we have recently used our F2 model of Mtb infection (Lyadova et al, 2010). In this model, (A/SnxI/St)F2 mice challenged with Mtb display different rates of TB progression.…”

Section: Not All Gr-1/ly-6g-positive Cells Accumulating In the Lungs mentioning

confidence: 99%

See 4 more Smart Citations

Inflammation and Immunopathogenesis of Tuberculosis Progression

Lyadova¹

2012

Understanding Tuberculosis - Analyzing the Origin of Mycobacterium Tuberculosis Pathogenicity

View full text Add to dashboard Cite

Section: T Lymphocytes In Tb Exacerbationsupporting

confidence: 83%

Section: Mtb Infection In Hosts With Genetic Differences In the Extenmentioning

confidence: 99%

Section: Mtb Infection In Hosts With Genetic Differences In the Extenmentioning

confidence: 99%

Section: Functional Activitiesmentioning

confidence: 99%

Section: Not All Gr-1/ly-6g-positive Cells Accumulating In the Lungs mentioning

confidence: 99%

See 3 more Smart Citations

Inflammation and Immunopathogenesis of Tuberculosis Progression

Lyadova¹

2012

Understanding Tuberculosis - Analyzing the Origin of Mycobacterium Tuberculosis Pathogenicity

View full text Add to dashboard Cite

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Naidoo,

Arumugam,

Ramsuran

2023

Advanced Genetics

View full text Add to dashboard Cite

Infectious diseases such as malaria, tuberculosis (TB), human immunodeficiency virus (HIV), and the coronavirus disease of 2019 (COVID‐19) are problematic globally, with high prevalence particularly in Africa, attributing to most of the death rates. There have been immense efforts toward developing effective preventative and therapeutic strategies for these pathogens globally, however, some remain uncured. Disease susceptibility and progression for malaria, TB, HIV, and COVID‐19 vary among individuals and are attributed to precautionary measures, environment, host, and pathogen genetics. While studying individuals with similar attributes, it is suggested that host genetics contributes to most of an individual's susceptibility to disease. Several host genes are identified to associate with these pathogens. Interestingly, many of these genes and polymorphisms are common across diseases. This paper analyzes genes and genetic variations within host genes associated with HIV, TB, malaria, and COVID‐19 among different ethnic groups. The differences in host–pathogen interaction among these groups, particularly of Caucasian and African descent, and which gene polymorphisms are prevalent in an African population that possesses protection or risk to disease are reviewed. The information in this review could potentially help develop personalized treatment that could effectively combat the high disease burden in Africa.

show abstract

LncRNA CCAT1 is overexpressed in tuberculosis patients and predicts their survival

Zhang

Zeng

et al. 2021

Immunity Inflam & Disease

View full text Add to dashboard Cite

Introduction: LncRNA CCAT1 promotes inflammatory responses, which contribute to tuberculosis. Therefore, CCAT1 may participate in tuberculosis.Therefore, we analyzed the involvement of CCAT1 in tuberculosis.Methods: Plasma samples were donated by a total of 200 patients with newly developed tuberculosis (N-TB), 102 patients with recurrent tuberculosis (R-TB), and 102 healthy controls on the day of admission. Plasma samples were also collected from N-TB and R-TB patients every month after the initiation of treatment for a total of 6 months. CCAT1 expression in these samples was detected by quantitative reverse transcription polymerase chain reaction. Levels of IFN-γ, IL-1β, iNOS, TNF-α, and IL-10 in plasma were determined by enzyme-linked immunosorbent assay. N-TB and R-TB patients were monitored for 2 months to analyze their survival.Results: On the day of admission, the highest levels of CCAT1, IFN-γ, IL-1β, iNOS, and TNF-α were detected in N-TB patients, followed by R-TB patients and controls, while the lowest levels of plasma IL-10 were detected in N-TB patients, followed by R-TB patients and controls. Across R-TB and N-TB patients, CCAT1 was inversely correlated with IL-10 but not closely correlated with other inflammatory factors. During the treatment, plasma CCAT1 levels decreased in both N-TB and R-TB patients. High CCAT1 levels were closely correlated with high mortality rates of both N-TB and R-TB patients. Conclusion: CCAT1 is overexpressed in tuberculosis patients and predicts their survival. Its function in tuberculosis may be related to IL-10.

show abstract

In Mice, Tuberculosis Progression Is Associated with Intensive Inflammatory Response and the Accumulation of Gr-1dim Cells in the Lungs

Cited by 70 publications

References 52 publications

Inflammation and Immunopathogenesis of Tuberculosis Progression

Inflammation and Immunopathogenesis of Tuberculosis Progression

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

LncRNA CCAT1 is overexpressed in tuberculosis patients and predicts their survival

Contact Info

Product

Resources

About