In-depth assessment of new Ti-based biocompatible materials

Design, Synthesis, and Preliminary Evaluation for Ti-Mo-Zr-Ta-Si Alloys for Potential Implant Applications

“…Lesser radiopaque tissue of up to 573 UH (at tibial compacta between 1222 and 2124 UH) was registered in the case of the Ti15Mo7Zr15Ta0.5Si alloy and the higher radio-opacity of approximately 755 UH (bone compact of about 2079 UH) in Ti15Mo7Zn15Ta0.75Si (Figure 8). The radio-opacity identified in the newly formed tissue around the implants is associated with the fibrous tissues with cartilage islands and ossification punctures formed during the bone remodeling and implants osseointegration, which is confirmed by histologic analyses [11,12,40]. In the case of the control and implanted rabbits, into the inner cambium there are present the mesenchymal cells which firstly differentiate in osteoprogenitor cells (Figure 9, first row of images), after that they are present in osteoblasts which are involved in osteoid production.…”

“…Lesser radiopaque tissue of up to 573 UH (at tibial compacta between 1222 and 2124 UH) was registered in the case of the Ti15Mo7Zr15Ta0.5Si alloy and the higher radio-opacity of approximately 755 UH (bone compact of about 2079 UH) in Ti15Mo7Zn15Ta0.75Si (Figure 8). The radio-opacity identified in the newly formed tissue around the implants is associated with the fibrous tissues with cartilage islands and ossification punctures formed during the bone remodeling and implants osseointegration, which is confirmed by histologic analyses [11,12,40].…”

“…In all cases, just nearby the alloys, the fibrous capsule generates a strong contact both with the surrounding new bone and the alloy pores to such an extent that it forms a bony sleeve around it [47] which is included into the callus after 60 days post implant [11,12].…”

“…Titanium biomaterials are highly sought for to their high resistance to breakage, stretching, and wear [10][11][12]. The combination of mechanical properties, corrosion resistance and biocompatibility recommend the titanium alloys for medical applications beside other conventional alloys (Co-Cr alloys, stainless steel) [13][14][15].…”

Biomimetic Deposition of Hydroxyapatite Layer on Titanium Alloys

“…This has prompted the improvement of another collection of Ti amalgams with biocompatible components such as Mo, Zr, Ta, Nb, and so on, which as of late, have been introduced to the market to overcome the toxicity associated with Ti-V/Al-based alloys currently in use. In addition, because the surface of the biomaterial plays a key role in the cellular response, the improvement of biological and tribological properties by surface modification is often necessary [6][7][8].…”