PLoS ONE volume 9, issue 6, Pe98416 2014 DOI: 10.1371/journal.pone.0098416 View full text
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Andrea Vannini, Davide Roncarati, Marco Spinsanti, Vincenzo Scarlato, Alberto Danielli

Abstract: The severity of symptoms elicited by the widespread human pathogen Helicobacter pylori is strongly influenced by the genetic diversity of the infecting strain. Among the most important pathogen factors that carry an increased risk for gastric cancer are specific genotypes of the cag pathogenicity island (cag-PAI), encoding a type IV secretion system (T4SS) responsible for the translocation of the CagA effector oncoprotein. To date, little is known about the regulatory events important for the expression of a f…

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