volume 30, issue 8, P727-738 2021
DOI: 10.1093/hmg/ddab053
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Abstract: Abstract Background Integration of functional genomic annotations when estimating polygenic risk scores (PRS) can provide insight into aetiology and improve risk prediction. This study explores the predictive utility of gene expression risk scores (GeRS), calculated using imputed gene expression and transcriptome-wide association study (TWAS) results. Methods The predictive utility of GeRS wa…

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