Improving the reliability of single-subject fMRI by weighting intra-run variability

Bertoldi, F. de; Finos, Livio; Maieron, Marta; Weis, Luca; Campanella, Martina; Ius, Tamara; Fadiga, Luciano

doi:10.1016/j.neuroimage.2015.03.076

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…The influence of these factors might be boosted by the combination with nonstandardized fMRI acquisitions, different instructions (e.g., in rs-fMRI eyes open, eyes closed), nonstandardized analysis methods, less suitable algorithms. While there is an increasing number of reports recommending larger-sample sizes (n > 100) for improving reliability (98), other attempts are needed to improve single-subject fMRI (99), which are compulsory for pushing forward clinical fMRI.…”

Section: Discussion: the Next Steps In Translational Neurosciencementioning

confidence: 99%

Current Challenges in Translational and Clinical fMRI and Future Directions

Specht

2020

Front. Psychiatry

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Translational neuroscience is an important field that brings together clinical praxis with neuroscience methods. In this review article, the focus will be on functional neuroimaging (fMRI) and its applicability in clinical fMRI studies. In the light of the "replication crisis," three aspects will be critically discussed: First, the fMRI signal itself, second, current fMRI praxis, and, third, the next generation of analysis strategies. Current attempts such as restingstate fMRI, meta-analyses, and machine learning will be discussed with their advantages and potential pitfalls and disadvantages. One major concern is that the fMRI signal shows substantial within-and between-subject variability, which affects the reliability of both taskrelated, but in particularly resting-state fMRI studies. Furthermore, the lack of standardized acquisition and analysis methods hinders the further development of clinical relevant approaches. However, meta-analyses and machine-learning approaches may help to overcome current shortcomings in the methods by identifying new, and yet hidden relationships, and may help to build new models on disorder mechanisms. Furthermore, better control of parameters that may have an influence on the fMRI signal and that can easily be controlled for, like blood pressure, heart rate, diet, time of day, might improve reliability substantially.

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Section: Discussion: the Next Steps In Translational Neurosciencementioning

confidence: 99%

Current Challenges in Translational and Clinical fMRI and Future Directions

Specht

2020

Front. Psychiatry

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“…Specifically, neuroradiological techniques, such as fMRI and 3D reconstruction of white matter tracts, represent useful tools to preoperatively analyze the three-dimensional relationships between the tumor and the neighboring cortical functional areas and subcortical pathways, respectively 6 , 18 , 42 – 44 . Intraoperative use of a guided navigation system enriched with functional and DTI data used in Series 2 significantly increase the possible EOR.…”

Section: Discussionmentioning

confidence: 99%

Multimodal integrated approaches in low grade glioma surgery

Ius

Mazzucchi

Tomasino

et al. 2021

Sci Rep

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Surgical management of Diffuse Low-Grade Gliomas (DLGGs) has radically changed in the last 20 years. Awake surgery (AS) in combination with Direct Electrical Stimulation (DES) and real-time neuropsychological testing (RTNT) permits continuous intraoperative feedback, thus allowing to increase the extent of resection (EOR). The aim of this study was to evaluate the impact of the technological advancements and integration of multidisciplinary techniques on EOR. Two hundred and eighty-eight patients affected by DLGG were enrolled. Cases were stratified according to the surgical protocol that changed over time: 1. DES; 2. DES plus functional MRI/DTI images fused on a NeuroNavigation system; 3. Protocol 2 plus RTNT. Patients belonging to Protocol 1 had a median EOR of 83% (28–100), while those belonging to Protocol 2 and 3 had a median EOR of 88% (34–100) and 98% (50–100) respectively (p = 0.0001). New transient deficits with Protocol 1, 2 and 3 were noted in 38.96%, 34.31% and 31,08% of cases, and permanent deficits in 6.49%, 3.65% and 2.7% respectively. The average follow-up period was 6.8 years. OS was influenced by molecular class (p = 0.028), EOR (p = 0.018) and preoperative tumor growing pattern (p = 0.004). Multimodal surgical approach can provide a safer and wider removal of DLGG with potential subsequent benefits on OS. Further studies are necessary to corroborate our findings.

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“…Another important issue with single‐case studies is the imperfect reliability of the fMRI data. One way to enhance the statistical power of fMRI results is to increase the number of trials (de Bertoldi et al, ). For this reason, five 4‐min fMRI runs were acquired in each session, for a total of 20 sessions.…”

Section: Discussionmentioning

confidence: 99%

Tracking Adult Literacy Acquisition With Functional MRI: A Single‐Case Study

Braga

Amemiya

Tauil

et al. 2017

Mind Brain and Education

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ABSTRACT-We evaluated neuro-functional changes associated with late acquisition of reading in an illiterate adult who underwent 20 longitudinal functional magnetic resonance imaging (fMRI) scans during 2 years, while the participant progressed from complete illiteracy to a modest level of alphabetical decoding. Initially, the participant did not activate neural circuits for reading when he was exposed to words; gradually, however, he began to present activation in left occipitotemporal cortex, at the visual word form area. This increase was accompanied by a decrease in face responses. Reading-related responses also emerged in language-related areas of the inferior frontal gyrus and temporal lobe. Additional activations in superior parietal lobe, superior frontal gyrus and posterior medial frontal cortex suggested that reading remained dependent on effortful executive attention and working memory processes. Nevertheless, the results indicate that adult plasticity can be sufficient to induce rapid changes in brain responses to written words and faces in an unschooled and illiterate adult.

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Improving the reliability of single-subject fMRI by weighting intra-run variability

Cited by 9 publications

References 33 publications

Current Challenges in Translational and Clinical fMRI and Future Directions

Current Challenges in Translational and Clinical fMRI and Future Directions

Multimodal integrated approaches in low grade glioma surgery

Tracking Adult Literacy Acquisition With Functional MRI: A Single‐Case Study

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