Improving the neutrality point uniformity for SG-FET-based DNA sensor

Kim, Hyo Eun; Schuck, Ariadna; Oh, Jongsu; Jung, Kyung‐Mo; Kim, Yong−Sang

doi:10.1016/j.sse.2019.107750

Cited by 6 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different experiments show that FET based on graphene functionalized with PBASE have high conductivity and sensitivity. Functionalization with PBASE neither induces defects in the AGNR, nor changes the electrical and physical properties of AGNR (Xu et al 2017 ; Ping et al 2016 ; Kim et al 2020 ; Vishnubhotla et al 2020 ; Béraud et al 2021 ; Hao et al 2020 ; Fernandes et al 2019 ; Tsang et al 2019 ; Mudusu et al 2020 ; Xia et al 2021 ; Tian et al 2020 , 2018 ; Ohno et al 2013 ; Guo et al 2011 ; Wu et al 2015 , 2017 ; Gao et al 2018 ; Forsyth et al 2017 ). Based on these results, we have functionalized AGNR with PBASE.…”

Section: Simulation Details and Methodsmentioning

confidence: 99%

“…There are some experimental studies that show that GFET DNA biosensors are a good candidate as a detector of DNA hybridization with high sensitivity, selectivity, stability, reproducibility, and reusability (Li et al 2019 ; Mensah et al 2020 ; Gao et al 2020 ; Kim et al 2020 ; Vishnubhotla et al 2020 ; Zheng et al 2015 ; Xu et al 2018 ; Hwang et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Kim et al ( 2020 ) proposed an improved technique for the transfer of graphene on the substrate which reduces damage and doping effects. Thus, they fabricated a GFET DNA biosensor with high transfer characteristics stability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Real-time label-free detection of DNA hybridization using a functionalized graphene field effect transistor: a theoretical study

Bagherzadeh-Nobari

Kalantarinejad²

2021

J Nanopart Res

View full text Add to dashboard Cite

Graphical abstract Detection of DNA hybridization with high sensitivity and accuracy plays a major role in clinical diagnosis and treatment. Despite intense experimental studies of graphene field effect transistor as DNA hybridization detector, the mechanism of detection and changes in the electrical properties of the device is not investigated in detail. To this end, we have investigated an armchair graphene nanoribbon (AGNR) interconnected between gold electrodes as a detector of DNA hybridization. Using non-equilibrium Green’s function method and density functional theory, the effect of 1-pyrenebutanoic acid succinimidyl ester (PBASE) linker, probe, and target DNA on the electrical properties of the device has been investigated at zero bias voltage. The results show that, after functionalization of AGNR with PBASE, the conductance of the device increases while functionalization with probe and target DNA leads to a decrease in conductance. The changes in the projected density of states on the AGNR and transmission around Fermi energy are the reason for the change in conductance of the system. In all cases, both charge transfer and electrostatic gating are responsible for the change in the electrical properties of the system. The results show that our device detects DNA hybridization with a sensitivity of 10% at zero bias voltage, and by applying a suitable gate voltage, it can show higher sensitivity.

show abstract

Section: Simulation Details and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Real-time label-free detection of DNA hybridization using a functionalized graphene field effect transistor: a theoretical study

Bagherzadeh-Nobari

Kalantarinejad²

2021

J Nanopart Res

View full text Add to dashboard Cite

show abstract

“…The intensity ratio of Raman spectra was measured ( Figure 4 a) to verify the quality of the graphene, where G and 2D peaks represent the number of graphene sheets. The properties of the graphene used in this study were already evaluated in our other works [ 34 , 38 , 50 ]. The graphene-based device introduced in this work is based on that coplanar structure.…”

Section: Resultsmentioning

confidence: 99%

“…Graphene is a single-layer material with a large surface area and paramount electronic and chemical properties that can increase the sensitivity and specificity of a biosensor when applied as an active layer [ 12 , 32 , 33 , 34 , 35 , 36 , 37 ]. A graphene-based field-effect transistor (GFET) has been applied as sensors by using bioreceptors that were immobilized over its surface while providing a controlled environment for detection and monitoring of physiological/biological processes [ 33 , 34 , 37 , 38 , 39 ]. The electrical response in a GFET is detected due to the presence of the charged biomolecules that were adsorbed on the surface of the graphene when an electric field is applied [ 32 , 34 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

A Graphene-Based Enzymatic Biosensor Using a Common-Gate Field-Effect Transistor for L-Lactic Acid Detection in Blood Plasma Samples

Schuck

Kim

Moreira

et al. 2021

Sensors

Self Cite

View full text Add to dashboard Cite

Lactate is an important organic molecule that is produced in excess during anaerobic metabolism when oxygen is absent in the human organism. The concentration of this substance in the body can be related to several medical conditions, such as hemorrhage, respiratory failure, and ischemia. Herein, we describe a graphene-based lactate biosensor to detect the concentrations of L-lactic acid in different fluids (buffer solution and plasma). The active surface (graphene) of the device was functionalized with lactate dehydrogenase enzyme using different substances (Nafion, chitosan, and glutaraldehyde) to guarantee stability and increase selectivity. The devices presented linear responses for the concentration ranges tested in the different fluids. An interference study was performed using ascorbic acid, uric acid, and glucose, and there was a minimum variation in the Dirac point voltage during detection of lactate in any of the samples. The stability of the devices was verified at up to 50 days while kept in a dry box at room temperature, and device operation was stable until 12 days. This study demonstrated graphene performance to monitor L-lactic acid production in human samples, indicating that this material can be implemented in more simple and low-cost devices, such as flexible sensors, for point-of-care applications.

show abstract

A Flexible, Transparent Chemosensor Integrating an Inkjet‐Printed Organic Field‐Effect Transistor and a Non‐Covalently Functionalized Graphene Electrode

Lai

Vlamidis

Mishra

et al. 2021

Adv Materials Technologies

View full text Add to dashboard Cite

portability, ease of use, and affordability, biochemical sensors are increasingly benefiting from the development of electronic technologies. In particular, the application of field-effect transistors (FETs) for biochemical sensing has attracted the attention of scientists since the demonstration of the ion-sensitive FET (ISFET) functionality. [1] FETs are capable of direct, label-free transduction of biochemical signals into electrical quantities and provide a local amplification that simplifies signal acquisition and processing. In addition, the specific properties of electronic technologies make this class of sensors ideal for the development of integrated, portable, user-friendly and affordable sensing systems. As FET-based biochemical sensors (namely bioFETs or chemFETs) are successfully used for broad biochemical sensing applications, [2][3][4] research has focused on providing these devices with novel properties that incorporate innovations of electronic technologies and materials science. In particular, mechanical flexibility and optical transparency are important for advanced biosensing devices. Mechanical flexibility ensures the possibility of adapting devices to complex shapes, and this property is fundamental to the development of new classes of Lab-on-a-Chip devices, [5][6][7] and more so for Point-of-Care, wearable, [8][9][10] or even implantable instrumentation. [11] Optical transparency is also crucial for device integration with wearable elements, [12] as well as when the integration of electronic and optical characterization is fundamental, such as in cell culturing or in medical applications, where optical inspection of analytes is fundamental. [13,14] In this sense, graphene and its derivatives have attracted the interest of the scientific community, because of their electrical properties, mechanical flexibility, robustness, durability, and transparency. Moreover, several studies have confirmed the biocompatibility and low cytotoxicity of graphene derivatives, [15] which makes them extremely attractive for biosensing applications. With respect to other conductive materials, graphene is highly stable and can be deposited by means of large-area processes, even by solution process techniques. State-of-theart, graphene-based bio-, and chemFETs have been reported for several applications, ranging from pH [16][17][18] and chemical This paper presents a novel chemical sensor that combines an organic, floating gate field-effect transistor and a functional graphene electrode, aimed at realizing the basic building block for novel biomedical sensor systems. A non-covalent functionalization of graphene with sensing peptides bearing a pyrene moiety is described as a way to provide graphene with chemical responsivity without affecting its electronic and optical features. Given the special properties of the materials and technologies used, and the intrinsic multi-modality of the active device, it is possible to develop a complete range of chemosensing devices by varying the chemical specificity of the immobi...

show abstract

Improving the neutrality point uniformity for SG-FET-based DNA sensor

Cited by 6 publications

References 27 publications

Real-time label-free detection of DNA hybridization using a functionalized graphene field effect transistor: a theoretical study

Real-time label-free detection of DNA hybridization using a functionalized graphene field effect transistor: a theoretical study

A Graphene-Based Enzymatic Biosensor Using a Common-Gate Field-Effect Transistor for L-Lactic Acid Detection in Blood Plasma Samples

A Flexible, Transparent Chemosensor Integrating an Inkjet‐Printed Organic Field‐Effect Transistor and a Non‐Covalently Functionalized Graphene Electrode

Contact Info

Product

Resources

About