Objective. The public health and economic crises caused by the COVID-19 pandemic have significant implications for parental mental health across the United States, especially when considering pre-existing economic and mental health disparities. We examined the association between COVID-19 experiences and parental mental distress. Method. In May 2020, using Qualtrics, we collected data cross-sectionally from 1,000 parents with at least one child aged 17 or younger in the U.S. Using a residualized change model, we examined the extent to which COVID-19-related experiences might be linked with parental mental distress, controlling for a wide range of sociodemographic characteristics. Results. Our multivariate regression analysis confirms adverse associations between certain COVID-19 experiences and parental mental distress. Specifically, economic hardship, anxiety, loneliness, stigma, and increased alcohol or substance use due to COVID-19 were significantly associated with poorer parental mental health. Conclusions. Our analysis highlights how COVID-19 and the economic hardships it causes might exacerbate the effects of COVID-19-related experiences on parental mental health, a population critical to the well-being and productivity of our next generations.