Improving a probabilistic cytoarchitectonic atlas of auditory cortex using a novel method for inter-individual alignment

Abstract

The human superior temporal plane, the site of the auditory cortex, displays a high 15 inter-individual macro-anatomical variation. This questions the validity of curvature based 16 alignment (CBA) methods for in vivo imaging data. Here, we have addressed this issue by 17 developing CBA+, which is a cortical surface registration method that uses prior macro-anatomical 18 knowledge. We validate this method by using cyto-architectonic areas on ten individual brains 19 (which we make publicly available). Compared to volumetric and standard surface registration, 20 CBA+ results in a more accurate cyto-architectonic auditory atlas. The improved correspondence of 21 micro-anatomy following the improved alignment of macro-anatomy validates the superiority of 22 CBA+ compared to CBA. In addition, we use CBA+ to align in vivo and post mortem data. This allows 23 projection of functional and anatomical information collected in vivo onto the cyto-architectonic 24 areas, which has potential to contribute to ongoing debate on the parcellation of the human 25 auditory cortex.

Using high spatial resolution fMRI to understand representation in the auditory network

“…It is still unclear how microanatomy, and therefore functional specialization, relates to this macroanatomical variation. The macroanatomical alignment of an individual hemisphere to a microanatomical atlas of human auditory cortex is therefore problematic ( Gulban et al, 2020 ). Third, maps of only one acoustic feature, frequency, are reliably reproduced across research labs ( Ahveninen et al, 2016 ; Besle et al, 2019 ; Da Costa et al, 2011 ; Formisano et al, 2003 ; Moerel et al, 2012 ; Saenz and Langers, 2014 ; Striem-Amit et al, 2011 ; Woods et al, 2010 ).…”

Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7 Tesla: Challenges and capabilities

“…The effect that this has on sampling the laminar activation profiles in auditory regions whose cytoarchitecture overlaps only partly with macro-anatomical features (see e.g. Gulban et al, 2020) is beyond the scope of this paper but could be an interesting venue for future investigations. What we did observe was that while the signal in the upper layers has the tendency to be larger than in middle and deeper layers, the signal decreases again at the pial surfaces.…”

Frequency and frequency modulation share the same predictive encoding mechanisms in human auditory cortex

“…Te3 lies on the lateral surface of the superior temporal gyrus, is an auditory association area, part of BA 22 and might correspond to parabelt areas in primates [67]. However, functional differences between human auditory fields and their correspondence to primates' auditory fields are still unclear; e.g., [67][68][69].…”