“…The pull-off force is not well understood and must be studied further to enable the advent of reliable micromanipulation techniques. Current methods to measure micro/nanoforces between surfaces are the surface force apparatus (SFA), , the atomic force microscope (AFM), − capacitive force sensors, or nanoindentation testers. , The modeling of pull-off force is mainly based on the different approaches based on the surface energies on the contact, − on the integration of the van der Waals forces between objects, − or on some hybrid approaches between both. , The adhesion force reduction was already obtained in liquid and dry medium by surface structuring − or chemical functionalization. ,− The last technique allows the switch of the force from attractive to repulsive by pH solution modification and improves the micro-object manipulation. ,, In the case of randomly rough surfaces, the fractal approach is one of the most usual ways to predict wear, adhesion force, or interaction forces. − …”