Improvement of psoriasis of the scalp with ketoconazole

Infection‑provoked psoriasis: Induced or aggravated (Review)

“…In addition, Elewski (69) reported a patient with psoriasis who developed active lesions in skin lesions of pityrosporum folliculitis. Several studies have demonstrated an improvement in scalp psoriasis following treatment with oral ketoconazole, combined with a decrease in the amount of yeast (70,71). Taken together, these findings support the association between psoriasis and Malassezia spp.…”

Association of Malassezia species with psoriatic lesions

“…25 The encouraging results obtained by treating scalp psoriasis using antifungal drugs led many investigators to associate Malassezia spp. with psoriasis, 15,16 but this association has not been unequivocally established. In this study, average number of colonies isolated from scalp lesions was significantly higher (P = 0.03) than those collected from the non-lesional area of the same patient.…”

“…in exacerbating psoriasis lesions. 15,16 Malassezia spp. produce inflammatory response by producing lipases and phospholipases leading to damage of the epidermal barrier function; aggravation of local immune response by production of inflammatory cytokines from keratinocytes and; production of cross-reactive allergens leading to sensitisation.…”

Oral Candida and psoriasis: Is there association? A systematic review and trial sequential analysis

“…and psoriasis was studied in parallel by a group at the University of Memphis, Tennesse, USA (Rosenberg & Belew, 1982a) and a group at the University of Frankfurt, Germany (Buslau et al, 1990). The U.S.…”

“…During the early 80's, the association between Candida spp. and psoriasis was studied in parallel by a group at the University of Memphis, Tennesse, USA (Rosenberg & Belew, 1982a) and a group at the University of Frankfurt, Germany (Buslau et al, 1990). The U.S. research group hypothesised that microbiological agents, including bacteria and fungi, might represent aetiological factors in psoriasis, specifically, Malassezia mycete for capitate psoriasis (Rosenberg & Belew, 1982b) and intestinal or cutaneous Candida spp.…”