Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement

Benson, Kathleen F.; Ager, David M.; Landes, Bernie; Aruoma, Okezie I.; Jensen, Gitte S.

doi:10.1016/j.ypmed.2012.02.001

Cited by 16 publications

(20 citation statements)

References 16 publications

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“…3 The scores for activities of daily living for this study population showed a dose-dependent relationship, with people reporting improved ability to perform daily activities during the week when they were consuming a 500 mg dose of ACE.…”

Section: Discussionmentioning

confidence: 76%

“…2 These changes in pain thresholds can result in altered pain perception and body posture compensation, which further accelerates the degradation of joint structures and reduces their functionality. 3 The inflammatory cascade is a response specific to our innate immune system and involves the release of inflammatory mediators from affected cells, the production of prostaglandins via cyclooxygenase (COX-1 and COX-2) activity, and the release of cytokines and growth factors from recruited immune cells. 4 Cytokines play a role in the initiation and maintenance of inflammatory states by either acting on nociceptors or indirectly stimulating the release of prostaglandins.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies

Jensen¹,

Attridge²,

Carter³

et al. 2016

NDS

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies

Jensen¹,

Attridge²,

Carter³

et al. 2016

NDS

Self Cite

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“…This is typical of chronic pain studies where an initial pain relief is associated with increased physical activity, resulting in either no further change or even a slight increase in pain scores due to the increased activity. 8 The noninvasive use of oral high-molecular-weight HA is an attractive intervention and the effectiveness may stem from accumulation of HA in connective tissue. The direct immune modulating properties of HA are multifaceted and may happen through CD44-and/or ICAM-1 signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

“…8 In addition to deteriorating joint health, chronic pain can result in adverse health effects, including an unbalanced posture due to body compensation, restricted range of motion, muscular hypertonicity and reduced muscle strength, and reduced activity levels. 5 HA, also referred to as hyaluronic acid, is a high molecular mass polysaccharide consisting of repeating N-acetylglucosamine and glucuronate subunits.…”

Section: Introduction Dmentioning

confidence: 99%

Oral Intake of a Liquid High-Molecular-Weight Hyaluronan Associated with Relief of Chronic Pain and Reduced Use of Pain Medication: Results of a Randomized, Placebo-Controlled Double-Blind Pilot Study

Jensen

Attridge

Lenninger

et al. 2015

Journal of Medicinal Food

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The goal for this study was to evaluate the effects of daily oral intake of a consumable liquid fermentate containing high-molecular-weight hyaluronan, as well as to perform a basic evaluation of safety and tolerability. A randomized, double-blind placebo-controlled study design was used to examine the effects of oral intake of hyaluronan on chronic pain conditions. Safety assessment included a complete blood count with differential, blood chemistry and electrocardiogram. The study duration was 4 weeks, where three tablespoons (45 mL) product or placebo was ingested during the first 2 weeks, and two tablespoons (30 mL) was consumed during the last 2 weeks. Seventy-eight people between the age of 19 and 71 years enrolled, and 72 people completed the study. Statistical analysis was performed using the two-tailed independent ttest for between-group significance and using the paired t-test for within-group significance. A reduction in pain scores was seen after 2 weeks of consumption of both placebo (P < .1) and active (P < .065) product; the reduction was more pronounced in the group consuming the active test product. Using ''within-subject'' analysis, a highly significant reduction in chronic pain scores was seen after 2 weeks of consumption of three tablespoons of active product (P < .001), whereas only a mild nonsignificant reduction in pain scores was seen in the placebo group. During the reduced intake for the last 2 weeks of study participation, pain scores showed a slight increase. During the last 2 weeks, a significant increase in the quality of sleep (P < .005) and level of physical energy (P < .05) was seen. The pain reduction during the initial 2 weeks was associated with significant reduction in the use of pain medication (P < .05). Consumption of an oral liquid formula containing highmolecular-weight hyaluronan was associated with relief of chronic pain.KEY WORDS: CBC ECG metabolic markers physical energy skin health

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“…Clinical evaluation of a beverage containing whole Acai (including the skin and pulp) showed improved joint ROM, 11 as did a clinical study on a complex blend, including the mushroom-based amino-acid ergothioneine. 12 In addition, anthocyanin-rich extracts from tart cherries have been shown to significantly reduce inflammation-induced thermal and mechanical hyperalgesia in rats. 13 Therefore, due to their potential for reducing inflammation, improving mobility, and modifying pain perception, interest in a variety of fruits containing high levels of polyphenols has increased.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Dried Apple Peel Powder Increases Joint Function and Range of Motion

Jensen

Attridge

Benson

et al. 2014

Journal of Medicinal Food

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The goal for this study was to evaluate the effects of consumption of dried apple peel powder (DAPP) on joint function and range of motion (ROM). Additional in vitro and clinical testing was performed to suggest specific mechanisms of action. An open-label clinical pilot study involved 12 healthy people with moderate loss of joint ROM and associated chronic pain. The subjects consumed 4.25 g DAPP daily for 12 weeks, with evaluations at baseline, 2, 4, 8, and 12 weeks. ROM was evaluated at each visit using dual digital inclinometry. Pain scores were collected using Visual Analogue Scales. Blood draws enabled testing of serum antioxidant protective capacity using the cellular antioxidant protection (CAP-e) bioassay. Additional in vitro testing involved testing of cyclooxygenase-2 (COX-2) and lipoxygenase inhibition, cellular antioxidant protection by the CAP-e bioassay, and formation of reactive oxygen species (ROS) by polymorphonuclear (PMN) cells by flow cytometry. Twelve weeks of consumption of DAPP was associated with improved ROM. DAPP provided antioxidants that were available to enter into and protect cells from oxidative damage in vitro, and consumption of DAPP for 12 weeks was associated with a statistically significant improvement in serum antioxidant protective status. DAPP inhibited both COX-2 and lipoxygenase enzymes, and pretreatment of inflammatory PMN cells with DAPP before inflammatory stimulus resulted in reduced ROS formation. This suggests multifaceted anti-inflammatory properties of DAPP. Consumption of DAPP was associated with improved joint function and improved serum antioxidant protection status. The observed pain reduction may be associated with the improved antioxidant status and linked to the apple polyphenols' anti-inflammatory effects.

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Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement

Cited by 16 publications

References 16 publications

Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies

Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies

Oral Intake of a Liquid High-Molecular-Weight Hyaluronan Associated with Relief of Chronic Pain and Reduced Use of Pain Medication: Results of a Randomized, Placebo-Controlled Double-Blind Pilot Study

Consumption of Dried Apple Peel Powder Increases Joint Function and Range of Motion

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