Improvement of Darier disease with diclofenac sodium 3% gel

Treatment of Darier's disease with diclofenac sodium 3% gel

“…Since the proposed mechanism of action of diclofenac sodium gel includes COX‐2 inhibition (Martin & Stockfleth, ), the reported patients (Millán‐Parrilla et al, ; Santos‐Alarcón et al, ) and our case would support the hypothesis of the pathogenic role of COX‐2 and PGE2 in DD. Our patient improved after 14 weeks therapy.…”

“…Our patient improved after 14 weeks therapy. In the three reported cases, the duration of treatment was 3, 6, and 8 months (Millán‐Parrilla et al, ; Santos‐Alarcón et al, ), but no explanation has been suggested for these differences yet.…”

“…Treatment can sometimes be challenging and varies according to the severity of the disease (Burge, ; Sehgal & Srivastava, ). To date, improvement of DD with diclofenac sodium 3% gel has only been reported in three patients (Millán‐Parrilla et al, ; Santos‐Alarcón, Sanchis‐Sanchez, & Mateu‐Puchades, ). Herein, we describe a new patient who has been treated with topical diclofenac sodium 3% gel with a good outcome.…”

Darier disease: etiology, pathogenesis, clinical entities, histological pattern and the main treatment principles

“…Одним из перспективных направлений в наружном лечении больных БД является применение селективных ин-гибиторов ЦОГ-2 (нестероидные противовоспали-тельные препараты), которые восстанавливают сни-жающуюся регуляцию экспрессии гена ATP2A2/ SERCA2 в кератиноцитах [19]. Так, ученые из Испа-нии [20] сообщили об успешном использовании ин-гибитора ЦОГ-2 диклофенака натрия (в виде 3% ге-ля) у пациентов с БД.…”

Successful treatment with diclofenac sodium 1% gel of a case of suspected Darier disease

“…Diclofenac sodium is one of the group of nonsteroidal anti‐inflammatory drugs (NSAIDs), and suppresses inflammation through inhibition of cyclooxygenase (COX)‐1 and COX‐2. A recent report described three patients with DD without descriptions of mutation analysis, and these all responded to topical diclofenac sodium 3% gel . In addition, we previously reported that COX‐2 inhibition and prostaglandin receptor type 4G (EP4) inhibition increased ATP2A2 mRNA expression in both ultraviolet (UV)‐irradiated and non‐UV‐irradiated normal human keratinocytes .…”