Improvement of bioavailability of poorly soluble racecadotril by solid dispersion with surface adsorption method: A case study

Enhancement of dissolution rate of racecadotril by liquisolid compact technology

“…Racecadotril is poorly water soluble with log P 3.3, a highly hydrophobic drug (Daravath, Kumari, 2021), makes it more ideal for the development of liquisolid tablet to enhance the solubility and rate of dissolution of drug. The current work was aimed to enhance the dissolution of racecadotril to improve the gastric absorption and there by the oral bioavailability by liquisolid technology.…”

“…Aqueous solubility of racecadotril was reported as 0.00176 mg/ml (Daravath, Kumari, 2021). The most important aspect in developing liquisolid compacts is the solubility of drug sample in a non-volatile vehicle system.…”

Enhancement of dissolution rate of racecadotril by liquisolid compact technology

“…Racecadotril is poorly water soluble with log P 3.3, a highly hydrophobic drug (Daravath, Kumari, 2021), makes it more ideal for the development of liquisolid tablet to enhance the solubility and rate of dissolution of drug. The current work was aimed to enhance the dissolution of racecadotril to improve the gastric absorption and there by the oral bioavailability by liquisolid technology.…”

“…Aqueous solubility of racecadotril was reported as 0.00176 mg/ml (Daravath, Kumari, 2021). The most important aspect in developing liquisolid compacts is the solubility of drug sample in a non-volatile vehicle system.…”

QbD-driven solid dispersion development for enhanced solubility and dissolution of the BCS Class II drug voriconazole as a model drug

“…The powders were sealed in aluminum pans and subjected to heating from 25 °C to 350 °C at a rate of 10 °C min -1 under a continuous nitrogen flow of 50 mL min -1 , thereby minimizing the risk of oxidative degradation. 25 2.7.3 Powder X-ray diffraction (PXRD). PXRD studies were conducted to determine the crystalline or amorphous nature of VC in the solid dispersion.…”

Design and Optimization of Inclusion Complexes Using QbD Principles: A strategy to enhance solubility and dissolution of Voriconazole

“…5 mg of powder was hermetically sealed in aluminum crucibles. The samples were heated from 25 to 350°C under a nitrogen atmosphere (50 mL/min) at a rate of 10°C/min [42].…”

“…XRD patterns of VC, β-CD, physical mixture, and the optimized complex were recorded using Cu radiation (wavelength 1.540 Å). The instrument was operated at 45 kV and 30 mA, and data were collected over a 2θ range of 0-90° [42].…”

Enhancement of dissolution rate of racecadotril by liquisolid compact technology

“…Racecadotril is poorly water soluble with log P 3.3, a highly hydrophobic drug (Daravath, Kumari, 2021), makes it more ideal for the development of liquisolid tablet to enhance the solubility and rate of dissolution of drug. The current work was aimed to enhance the dissolution of racecadotril to improve the gastric absorption and there by the oral bioavailability by liquisolid technology.…”

“…Aqueous solubility of racecadotril was reported as 0.00176 mg/ml (Daravath, Kumari, 2021). The most important aspect in developing liquisolid compacts is the solubility of drug sample in a non-volatile vehicle system.…”

QbD-driven solid dispersion development for enhanced solubility and dissolution of the BCS Class II drug voriconazole as a model drug

“…The powders were sealed in aluminum pans and subjected to heating from 25 °C to 350 °C at a rate of 10 °C min -1 under a continuous nitrogen flow of 50 mL min -1 , thereby minimizing the risk of oxidative degradation. 25 2.7.3 Powder X-ray diffraction (PXRD). PXRD studies were conducted to determine the crystalline or amorphous nature of VC in the solid dispersion.…”

Design and Optimization of Inclusion Complexes Using QbD Principles: A strategy to enhance solubility and dissolution of Voriconazole

“…5 mg of powder was hermetically sealed in aluminum crucibles. The samples were heated from 25 to 350°C under a nitrogen atmosphere (50 mL/min) at a rate of 10°C/min [42].…”

“…XRD patterns of VC, β-CD, physical mixture, and the optimized complex were recorded using Cu radiation (wavelength 1.540 Å). The instrument was operated at 45 kV and 30 mA, and data were collected over a 2θ range of 0-90° [42].…”

Enhancement of dissolution rate of racecadotril by liquisolid compact technology

“…Racecadotril is poorly water soluble with log P 3.3, a highly hydrophobic drug (Daravath, Kumari, 2021), makes it more ideal for the development of liquisolid tablet to enhance the solubility and rate of dissolution of drug. The current work was aimed to enhance the dissolution of racecadotril to improve the gastric absorption and there by the oral bioavailability by liquisolid technology.…”

“…Aqueous solubility of racecadotril was reported as 0.00176 mg/ml (Daravath, Kumari, 2021). The most important aspect in developing liquisolid compacts is the solubility of drug sample in a non-volatile vehicle system.…”

QbD-driven solid dispersion development for enhanced solubility and dissolution of the BCS Class II drug voriconazole as a model drug

“…The powders were sealed in aluminum pans and subjected to heating from 25 °C to 350 °C at a rate of 10 °C min -1 under a continuous nitrogen flow of 50 mL min -1 , thereby minimizing the risk of oxidative degradation. 25 2.7.3 Powder X-ray diffraction (PXRD). PXRD studies were conducted to determine the crystalline or amorphous nature of VC in the solid dispersion.…”

Design and Optimization of Inclusion Complexes Using QbD Principles: A strategy to enhance solubility and dissolution of Voriconazole

“…5 mg of powder was hermetically sealed in aluminum crucibles. The samples were heated from 25 to 350°C under a nitrogen atmosphere (50 mL/min) at a rate of 10°C/min [42].…”

“…XRD patterns of VC, β-CD, physical mixture, and the optimized complex were recorded using Cu radiation (wavelength 1.540 Å). The instrument was operated at 45 kV and 30 mA, and data were collected over a 2θ range of 0-90° [42].…”