Improved survival in resected oesophageal and gastric adenocarcinomas over a decade: the Royal Marsden experience 2001–2010

Fontana, Elisa; Smyth, Elizabeth; Cunningham, David; S, Rao; Watkins, David; Allum, William; Thompson, J. N.; Waddell, Tom; Peckitt, Clare; Chau, Ian; Starling, Naureen

doi:10.1007/s10120-015-0561-5

Cited by 9 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last few years, the incidence and mortality from gastric cancer have declined significantly, however, it is not clear whether these benefits are being dispersed equally across different geographic regions [11]. Our research in neuroendocrine tumors identified socio-demographic disparities in cancer outcomes [12].…”

Section: Discussionmentioning

confidence: 83%

Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study

Rana

Gosain

Lemini

et al. 2020

Cancers

View full text Add to dashboard Cite

Background: Gastric cancer is one of the leading causes of cancer-related mortality worldwide, accounting for 8.2% of cancer-related deaths. The purpose of this study was to investigate the geographic and sociodemographic disparities in gastric adenocarcinoma patients. Methods: We conducted a retrospective study in gastric adenocarcinoma patients between 2004 and 2013. Data were obtained from the National Cancer Data Base (NCDB). Univariate and multivariable analyses were performed to evaluate overall survival (OS). Socio-demographic factors, including the location of residence [metro area (MA) or rural area (RA)], gender, race, insurance status, and marital status, were analyzed. Results: A total of 88,246 [RA, N = 12,365; MA, N = 75,881] patients were included. Univariate and multivariable analysis showed that RA had worse OS (univariate HR = 1.08, p < 0.01; multivariate HR = 1.04; p < 0.01) compared to MA. When comparing different racial backgrounds, Native American and African American populations had poorer OS when compared to the white population; however, Asian patients had a better OS (multivariable HR = 0.68, p < 0.01). From a quality of care standpoint, MA patients had fewer median days to surgery (28 vs. 33; p < 0.01) with fewer positive margins (6.3% vs. 6.9%; p < 0.01) when compared to RA patients. When comparing the extent of lymph node dissection, 19.6% of MA patients underwent an extensive dissection (more than or equal to 15 lymph nodes) in comparison to 18.7% patients in RA (p = 0.03). Discussion: This study identifies socio-demographic disparities in gastric adenocarcinoma. Future health policy initiatives should focus on equitable allocation of resources to improve the outcomes.

show abstract

Section: Discussionmentioning

confidence: 83%

Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study

Rana

Gosain

Lemini

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Gastric cancer is a common digestive tract cancer with the fourth leading incidence rate and the second highest mortality rate in the world (8). The pathogenesis of gastric cancer is not yet fully understood.…”

Section: Discussionmentioning

confidence: 99%

Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice

Wang

2016

Oncology Letters

View full text Add to dashboard Cite

The aim of the present study was to investigate the effect of aspirin on the cell proliferation and migration of gastric cancer cells in p53-knockout mice. Twenty p53−/− male mice aged 6 to 7 weeks, with an average weight of 20±3 g were used. The model of gastric cancer was established by the implantation of a mouse forestomach carcinoma cell line, subcutaneously, at the back of the neck, and then the mice were randomly divided into two groups after establishment of the model (control group, n=10; experimental group, n=10). Aspirin (250 mg/kg) was added to the food in the experimental group one day before model establishment, until the end of the experiment. Mice in the control group were given regular food without aspirin. All mice were sacrificed 3 months afterwards, and gastric cancer tissues were harvested. MTT assay was used to detect the proliferation of the tumor cells. Tumor cell number was also observed. Migration ability was detected by scratch assay, and E-cadherin protein expression was evaluated by immunofluorescence. The results revealed that the proliferation ability of tumor cells in the experimental group was lower than that in the control group. In addition, cell numbers were significantly decreased and the migration ability was diminished. The expression of E-cadherin was also increased in the experimental group, and the differences were statistically significant (P<0.05). In conclusion, aspirin inhibited the cell proliferation and migration of gastric cancer cells in mice.

show abstract

“…Gastric cancer (GC) is the third leading cause of cancer‐related death worldwide . Only few patients can undergo curative surgery . The response rate to multiagent chemotherapy is 50% or greater, but median survival is still limited .…”

Section: Introductionmentioning

confidence: 99%

“…Only few patients can undergo curative surgery . The response rate to multiagent chemotherapy is 50% or greater, but median survival is still limited . Therefore, new targeted approaches are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells

Barat

Chen

Bui

et al. 2017

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Cancer stem cells (CSC) are associated with tumor resistance and are characterized in gastric cancer (GC). Studies have indicated that Notch and wnt‐beta‐catenin pathways are crucial for CSC development. Using CD44+ CSCs, we investigated the role of these pathways in GC carcinogenesis. We performed cell proliferation, wound healing, invasion, tumorsphere, and apoptosis assays. Immunoblot analysis of downstream signaling targets of Notch and wnt‐beta‐catenin were tested after gamma‐secretase inhibitor IX (GSI) treatment. Immunohistochemistry, immunofluorescence, and Fluorescence activated cell sorting (FACS) were used to determine CD44 and Hairy enhancer of split‐1 (Hes1) expression in human GC tissues. CD44+ CSCs were subcutaneously injected into NMR‐nu/nu mice and treated with vehicle or GSI. GC patients with expression of CD44 and Hes1 showed overall reduced survival. CD44+ CSCs showed high expression of Hes1. GSI treatment showed effective inhibition of cell proliferation, migration, invasion, tumor sphere formation of CD44+ CSCs, and induced apoptosis. Importanly, Notch1 was found to be important in mediating a crosstalk between Notch and wnt‐beta‐catenin in CD44+ CSCs. Our study highlights a crosstalk between Notch and wnt‐beta‐catenin in gastric CD44+ CSCs. Expression of CD44 and Hes1 is associated with patient overall survival. GSI could be an alternative drug to treat GC. Stem Cells Translational Medicine 2017;6:819–829

show abstract

Improved survival in resected oesophageal and gastric adenocarcinomas over a decade: the Royal Marsden experience 2001–2010

Cited by 9 publications

References 25 publications

Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study

Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study

Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice

Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells

Contact Info

Product

Resources

About