1987
DOI: 10.1055/s-2007-1020217
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Abstract: The effect of creatine phosphate in potassium cardioplegia was studied in a pig heart model in vivo. Fifteen pigs divided into two groups were placed on cardiopulmonary bypass and subjected to 1 hour of cardioplegic arrest at normothermia. In group I (control), in which a potassium cardioplegic solution was used, only two out of eight animals could successfully be weaned from bypass. In group II, on the other hand, in which creatine phosphate (10 mmol/l) was added to the cardioplegic solution, six out of seven… Show more

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Cited by 12 publications
(6 citation statements)
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(11 reference statements)
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“…Furthermore, ex vivo rat hearts subjected to ischaemia-reperfusion injury had almost complete recovery of heart function when PCr was included in the perfusion buffer [46]. Cardioplegic solutions supplemented with PCr improved the ability of the heart to perform work following cardiopulmonary bypass in pigs [47], and improved myocardial protection in rat hearts [48]. This apparently translates to humans since significant myocardial protection was reported in patients undergoing coronary artery bypass surgery that received PCr before, during, and after cardioplegic bypass surgery [49].…”
Section: Strategies To Elevate Myocardial Creatine Levelsmentioning
confidence: 99%
“…Furthermore, ex vivo rat hearts subjected to ischaemia-reperfusion injury had almost complete recovery of heart function when PCr was included in the perfusion buffer [46]. Cardioplegic solutions supplemented with PCr improved the ability of the heart to perform work following cardiopulmonary bypass in pigs [47], and improved myocardial protection in rat hearts [48]. This apparently translates to humans since significant myocardial protection was reported in patients undergoing coronary artery bypass surgery that received PCr before, during, and after cardioplegic bypass surgery [49].…”
Section: Strategies To Elevate Myocardial Creatine Levelsmentioning
confidence: 99%
“…Thomas’ Hospital” cardioplegic solution) during prolonged ischemic arrest and that together they act additively to provide a greater protection . In a rat model of normothermic ischemia and in a pig model of the same condition, addition of PCr to the cardioplegic solution improved left ventricular isovolumetric function and caused a better maintenance of high‐energy phosphates during ischemia.…”
Section: Creatine and Myocardial Ischemiamentioning
confidence: 99%
“…Previous studies have shown that supplementation of cardioplegic solutions with exogenous phosphocreatine can significantly improve myocardial protection, e.g. in pigs [ 33 ] and in patients [ 34 ] undergoing coronary artery bypass surgery, and in ex vivo rat hearts [ 35 ]. However, it should be noted that phosphocreatine is not a substrate for cellular uptake via the CrT [ 36 ].…”
Section: Discussionmentioning
confidence: 99%