volume 7, issue 11, P1004-1021 2015
DOI: 10.18632/aging.100842
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Jamie N. Justice, Lawrence C. Johnson, Allison E. DeVan, Charmion Cruickshank-Quinn, Nichole Reisdorph, Candace J. Bassett, Trent D. Evans, Forrest A. Brooks, Nathan S. Bryan, Michel B. Chonchol, Tony Giordano, Matthew B. McQueen, Douglas R. Seals

Abstract: Advancing age is associated with reductions in nitric oxide bioavailability and changes in metabolic activity, which are implicated in declines in motor and cognitive function. In preclinical models, sodium nitrite supplementation (SN) increases plasma nitrite and improves motor function, whereas other nitric oxide-boosting agents improve cognitive function. This pilot study was designed to translate these findings to middle-aged and older (MA/O) humans to provide proof-of-concept support for larger trials. SN…

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