Improved Manufacturing Quality and Bonding of Laser Machined Microfluidic Systems

Mohammed, Mazher Iqbal; Quayle, Kim; Alexander, Richard; Doeven, Egan H.; Nai, Ryan; Haswell, Stephen J.; Kouzani, Abbas Z.; Gibson, Ian

doi:10.1016/j.protcy.2015.07.035

Cited by 10 publications

(10 citation statements)

References 8 publications

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“…The standard deviation over the flat first half of the channel for 15% power is 5.2 μm, of similar magnitude to previous reports (Mohammed et al 2015 ), for single pass CO 2 laser channel engraving. The channel depths measured for this data show a close to linear relationship with laser power up to 50%, Fig.…”

Section: Resultssupporting

confidence: 90%

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Microfluidic ratio metering devices fabricated in PMMA by CO2 laser

Tweedie

Maguire

2020

Microsyst Technol

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We describe microfluidic fabrication results achieved using a 10.6 μm CO2 engraving laser on cast PMMA, in both raster and vector mode, with a 1.5″ lens and a High Power Density Focussing Optics lens. Raster written channels show a flatter base and are more U-shaped, while vector written channels are V shaped. Cross-sectional images, and, where possible, stylus profilometry results are presented. The sides of V-grooves become increasing steep with laser power, but broader shallower channels may be produced in vector mode by laser defocus, as illustrated. Smoothing of raster engraved channels by heated IPA etch, and transparency enhancement by CHCl3 vapour treatment are briefly discussed. An asymmetric Y meter is discussed as one method of diluting acid into seawater for dissolved CO2 analysis. Alternatively, microfluidic snake channel restrictors of different lengths in 2 channels may achieve the same result. Samples are fabricated with bases bonded by CHCl3 vapour treatment, and the devices are flow tested with either dilute food dye or DI water. Microfluidics fabricated in this manner have applications in ocean sensing of dissolved CO2 and other analytes, as well as broader sensing measurements, including biomedical sensors.

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Section: Resultssupporting

confidence: 90%

“…Here, the lid or base, and/or the microchannel patterned substrate are exposed to a solvent vapour e.g. CHCl 3 (Mohammed et al 2015 ; Sun et al 2015 ), to soften them, and then pressed together, preferably, in a temperature and pressure controlled hot embosser, which strengthens the bond, while driving off excess solvent.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic ratio metering devices fabricated in PMMA by CO2 laser

Tweedie

Maguire

2020

Microsyst Technol

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“…Employing Xurography for the fabrication of microfluidics devices, features down to

width and

thick can be obtained in minutes with no masks [ 28 ]. CO 2 laser-cut is used for processing different materials, like PMMA (Poly-Methyl-MethAcrylate) [ 29 ], PDMS [ 30 ], Mylar [ 31 , 32 , 33 , 34 , 35 , 36 ], and Poly-lactic acid (PLA) [ 37 , 38 ]. Among the techniques used to bond two different layers, we can find heat press [ 38 ], heat lamination [ 28 ], Pressure-Sensitive Adhesive (PSA) [ 39 , 40 ], or solvent bonding [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications

Paoli

Giuseppe

Badiola-Mateos

et al. 2021

Sensors

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Microfabrication and Polydimethylsiloxane (PDMS) soft-lithography techniques became popular for microfluidic prototyping at the lab, but even after protocol optimization, fabrication is yet a long, laborious process and partly user-dependent. Furthermore, the time and money required for the master fabrication process, necessary at any design upgrade, is still elevated. Digital Manufacturing (DM) and Rapid-Prototyping (RP) for microfluidics applications arise as a solution to this and other limitations of photo and soft-lithography fabrication techniques. Particularly for this paper, we will focus on the use of subtractive DM techniques for Organ-on-a-Chip (OoC) applications. Main available thermoplastics for microfluidics are suggested as material choices for device fabrication. The aim of this review is to explore DM and RP technologies for fabrication of an OoC with an embedded membrane after the evaluation of the main limitations of PDMS soft-lithography strategy. Different material options are also reviewed, as well as various bonding strategies. Finally, a new functional OoC device is showed, defining protocols for its fabrication in Cyclic Olefin Polymer (COP) using two different RP technologies. Different cells are seeded in both sides of the membrane as a proof of concept to test the optical and fluidic properties of the device.

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“…Considering the contamination in many microfluidic applications, singleuse devices are desired, making lithography not the first choice of production. Apart from lithographic patterning, many other production techniques have been developed for micropatterning of microfluidic channels, such as hot embossing [10], injection molding [11], casting, 3D printing [12], and laser ablation [13].…”

Section: Introductionmentioning

confidence: 99%

Rapid prototyping of noncontact microwave microfluidic devices for sensing applications

Camli¹,

Erden²,

Sezgen³

et al. 2021

J. Micromech. Microeng.

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Microfluidics is an innovative technological platform with a vast potential to streamline processes in biology, chemistry, and biomedical fields. Microfluidic integrated biosensors attract much attention due to extreme miniaturization, low sample consumption, and increased homogeneity in mixing conditions, leading to enhanced sensitivity. Nowadays, many researchers focus on inexpensive and flexible laser production of polymer-based microfluidic devices for sensing applications due to their ease of production and rapid processing benefits. In this article, we present some key factors for the simple and rapid production of microfluidic components of the microwave sensor by using the CO2 laser ablation technique. The technique does not require any cleanroom or complex laboratory setups and provides short fabrication times for prototyping. It is observed that, at high laser power (30 W) and low scan speed (125 cm s−1), both the channel depth and the surface roughness increase greatly as opposed to channel waviness. It is also demonstrated that heat treatment is a viable method to reduce the channel roughness with a trade of channel depth. In the second section, prepared channels are bonded onto the split ring resonators (SRRs) fabricated using polymethyl methacrylate as a substrate. Power reflection measurements from SRR are performed using a continuous flow system that injects 100 mM glucose solutions into the channels. Change of dielectric constant due to glucose loading generates a meaningful resonance frequency shift, showing a possible use scenario of the device as a biosensor.

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Improved Manufacturing Quality and Bonding of Laser Machined Microfluidic Systems

Cited by 10 publications

References 8 publications

Microfluidic ratio metering devices fabricated in PMMA by CO2 laser

Microfluidic ratio metering devices fabricated in PMMA by CO2 laser

Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications

Rapid prototyping of noncontact microwave microfluidic devices for sensing applications

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