Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after<i>Sambucus ebulus</i>L. fruit infusion consumption

Ivanova, Diana; Tasinov, Oskan; Kiselova-Kaneva, Yoana

doi:10.3109/09637486.2014.898256

Cited by 27 publications

(29 citation statements)

References 41 publications

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“…In addition, oxygen free radicals and reactive oxygen species can also damage vascular endothelial function through leukocyte activation. Furthermore, urate crystals are deposited in the arterial wall, which induces inflammation, stimulates mast cells, induces lipid infiltration, and further damages the intimal cells of the arteries, thus blocking apolipoprotein B (apoB) metabolism, and ultimately leads to the aggravation of atherosclerosis 47,48 . Similarly,…”

Section: Discussionmentioning

confidence: 99%

Association between uric acid and brachial-ankle pulse wave velocity: secondary analysis of data from a cross-sectional study

Luo

Zhuo

2020

Sci Rep

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At present, the association between uric acid (UA) and brachial-ankle pulse wave velocity (bapWV)has not been well clarified. This study is the second analysis based on a cross-sectional study. 912 participants (average age is 51.5 ± 9.6 years) who underwent medical health examinations were included in this study, UA levels and baPWV were measured. Participants were divided into four groups according to UA levels (Quantile 1: 2.00-4.10 mg/dL; Quantile 2: 4.20-5.20 mg/dL; Quantile 3: 5.30-6.00 mg/dL and Quantile 4: 6.10-9.80 mg/dL), and the differences of baPWV between the four groups were compared. Univariate analysis showed a positive correlation between UA and baPWV [(Quantile 2 vs Quantile 1: 8.85 (−36.05, 53.75); Quantile 3 vs Quantile 1: 60.32 (13.22, 107.42) and Quantile 4 vs Quantile 1: 80.34 (36.19, 124.49)]. After adjusting for confounding factors, the positive correlation between UA and baPWV still exists [(Quantile 2 vs Quantile 1: −9.92 (−60.16, 40.32); Quantile 3 vs Quantile 1: 82.34 (4.00, 160.68) and Quantile 4 vs Quantile 1: 143.13 (0.75, 285.51)]. Furthermore, curve fitting showed that UA and baPWV had a non-linear positive correlation. In conclusion, elevated UA were associated with baPWV, suggesting that UA could be used as a predictor of atherosclerosis.With the continuous development of social economy and the change of people's eating habits, cardiovascular disease has become the main cause of death worldwide 1-4 , especially the number of cardiovascular diseases has been increasing in recent years, this trend will be more pronounced in the future. As is known to all, cardiovascular disease has the clinical characteristics of high incidence, high mortality and high disability rate 5,6 . Once cardiovascular disease occurs, it will bring a huge economic burden to patients and national health security system. Therefore, early identification of cardiovascular risk factors and timely intervention is the focus of clinicians and medical and health institutions.Previous studies have shown that atherosclerosis is an important pathological of cardiovascular disease 7-9 , but early atherosclerosis is lack of specific manifestations, and patients do not have obvious clinical symptoms, thus atherosclerosis is easy to be ignored in its early stages 10 . Therefore, how to identify arterial stiffness early is an important strategy to prevent cardiovascular diseases. With the gradual development of medical equipment and the continuous improvement of people's attention to cardiovascular diseases, the technology of evaluating arterial stiffness by non-invasive method has become the focus of clinicians 11,12 . Brachial-ankle pulse wave velocity (baPWV) 13-16 is the measurement of pulse wave velocity between brachial artery and ankle artery, which mainly reflects the stiffness of the vascular wall of peripheral large and middle arteries 17 . The larger the baPWV value, the higher the degree of arterial stiffness, and then the greater risk of cardiovascular diseases. At present, baPWV has been used as a non-invasi...

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Section: Discussionmentioning

confidence: 99%

Association between uric acid and brachial-ankle pulse wave velocity: secondary analysis of data from a cross-sectional study

Luo

Zhuo

2020

Sci Rep

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“…In normal-weight and overweight volunteers, the intake of red-fleshed orange juice (red orange juice) [140] and polyphenol-rich chokeberry juice had similar effects, thanks to the antioxidant and reducing properties of citrus flavonoids, carotenoids, and lycopene, improving the risk factors for metabolic syndrome, including improvements in insulin resistance and blood pressure [141]. Also, the combined supplementation of grape pomace and omija fruit extracts [142], as well as Sambucus ebulus fruit infusion [143], improved obesity-related dyslipidemia, inflammation, and serum oxidative stress, however, without evident effects on patient body weight. Both body weight and lipid profile were, instead, improved by green tea (Camelia sinensis) intake [144], which also had a positive effect on DNA repair via HO-1 expression, which is a cytoprotective enzyme against pro-oxidant changes [145].…”

Section: Cardiovascular Riskmentioning

confidence: 99%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.

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“…In traditional medicine, extracts of different parts of the herb like leaves, rhizome, root and fruitsused in treating some inflammatory cases such as, bee and nettle bites, arthritis and sore-throat, burns and infectious wounds, edema, eczema, urticaria, hemorrhoids, rheumatism (6,7,9). In other studies some effects of S. ebulus were investigated Anti-inflammatory and antinociceptive (10), antioxidant (11,12) anticancer (13) and antibacterial (14) effects. Since there is no specific treatment, moreover because of current treatments issues and according to effects and properties of S. ebulus we aimed to prepare a topical formulation from methanolic extract of this herb, to investigate its effects on uremic pruritus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sambucus ebulus topical preparation on uremic pruritus

et al. 2017

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Uremic pruritus is a common and distressing symptom that affects more than 40% of patients undergoing hemodialysis. Several medications as well as topical preparation have been used for relief this condition. Sambucus ebulus has been shown antiinflammatory and wound healing effects. In this research, the antipruritic effect of S. ebulus fruit extract was evaluated on patients with uremic pruritus. S. ebulus fruits were collected from Sari suburb, Iran. Fruits were dried at room temperature and several fractions of extract were prepared. After formulating suitable gel (2%) a randomized, single blind, placebo-controlled clinical trial was performed in 78 patients (40 patients received S. ebulus topical gel 2% and 38 patients received placebo gel) for 8 weeks and the changes in hyperuremic induced pruritus severity were evaluated. Sixty one patients completed the study. The Pruritus severity index was reduced in both groups after 8 weeks' treatment. S. ebulus topical gel showed more effect than placebo, but this difference was not statistically significant. The results showed that S. ebulus topical gel can reduce uremic pruritus severity, and more study with higher extract concentration or more cases is proposed.

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Improved lipid profile and increased serum antioxidant capacity in healthy volunteers afterSambucus ebulusL. fruit infusion consumption

Cited by 27 publications

References 41 publications

Association between uric acid and brachial-ankle pulse wave velocity: secondary analysis of data from a cross-sectional study

Association between uric acid and brachial-ankle pulse wave velocity: secondary analysis of data from a cross-sectional study

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Effect of Sambucus ebulus topical preparation on uremic pruritus

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